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Authors
Advisor(s)
Abstract(s)
O presente relatório incorpora as três principais vertentes da Unidade Curricular de Estágio
do Mestrado Integrado em Ciências Farmacêuticas: a vertente de Investigação (Capítulo I), de
Farmácia Hospitalar (Capítulo II) e de Farmácia Comunitária (Capítulo III).
O primeiro capítulo elucida sobre os conhecimentos adquiridos em relação à terapêutica
inovadora dos inibidores dos checkpoints imunitários que estão a revolucionar o tratamento
do cancro, sobretudo do cancro metastático. O objetivo deste estudo prendeu-se com a
investigação dos inibidores dos checkpoints imunitários presentes no mercado farmacêutico, o
seu mecanismo de ação e sobretudo os seus efeitos adversos imunitários. Tratando-se de uma
terapêutica inovadora com efeitos adversos tão distintos dos conhecidos para outras
terapêuticas anticancerígenas, torna-se fulcral e imperativo fazer os possíveis para tentar
compreender ao máximo as possíveis razões para o seu aparecimento e qual a melhor maneira
de lidar com eles. Foi feita também uma análise dos principais pontos críticos encontrados
nas três guidelines mais utilizadas como instrumento de trabalho na resolução dos efeitos
adversos imunitários. Para realizar este estudo, foi feita uma revisão bibliográfica em três
bases de dados científicas, PubMed, Scopus e Clarivate Analytics, com a inclusão de artigos
publicados no período compreendido entre 1 de janeiro de 2018 e 9 de fevereiro de 2019,
tendo sido também consultado o Resumo das Características do Medicamento de cada um dos
inibidores dos checkpoints imunitários aprovados para utilização pela European Medicines
Agency (EMA) e U.S. Food and Drug Administration (FDA) até julho de 2019.
O segundo capítulo reflete a experiência profissionalizante em Farmácia Hospitalar, que teve
lugar nos Serviços Farmacêuticos da Unidade Local de Saúde de Castelo Branco e o terceiro
capítulo cinge-se ao estágio em Farmácia Comunitária realizado na Farmácia Antunes, em
Miranda do Corvo.
Neste relatório estão também presentes os vários trabalhos apresentados em congressos e
conferências e que pretenderam dar a conhecer novas perspectivas e abordagens deste tema.
The present report incorporates the three main areas of the Curricular Unit of Internship of the Integrated Master Course in Pharmaceutical Sciences: Investigation (Chapter I), the Hospital Pharmacy (Chapter II) and Community Pharmacy (Chapter III). The first chapter enlightens about the knowledge acquired in relation to the innovative therapy of immune checkpoints inhibitors that are revolutionising cancer treatment, specially metastastized cancer. The aim of this study was to investigate the immune checkpoint inhibitors present in the pharmaceutical market, their mechanism of action and mostly about their immune-related adverse events. Being an innovative therapy with such distinct adverse events from those known for other anti-cancerous therapies, makes it important and imperative to try as much as possible to understand the possible reasons for their appearance and the best way to treat them. It was also accomplished an analysis of the principal critical points found in the three guidelines more often used as a work tool in the resolution of the immune-related adverse events. To perform this study, a bibliographic review was accomplished in three scientific databases: PubMed, Scopus and Clarivate Analytics, with the inclusion of articles published in the period between 1st January 2018 and 9th February 2019, being also consulted the Summary of Product Characteristics of each one of the immune checkpoint inhibitors approved by European Medicines Agency (EMA) and U.S. Food and Drug Administration (FDA) until July 2019. The second chapter reflects the professionalizing experience in Hospital Pharmacy which took place in the Pharmaceutical Services of the Local Health Unit of Castelo Branco and the third chapter is about the Community Pharmacy internship made in Farmácia Antunes, in Miranda do Corvo. In this report there are also present the different works shown in congresses and conferences and that intended to make known new perspectives and approaches about this theme.
The present report incorporates the three main areas of the Curricular Unit of Internship of the Integrated Master Course in Pharmaceutical Sciences: Investigation (Chapter I), the Hospital Pharmacy (Chapter II) and Community Pharmacy (Chapter III). The first chapter enlightens about the knowledge acquired in relation to the innovative therapy of immune checkpoints inhibitors that are revolutionising cancer treatment, specially metastastized cancer. The aim of this study was to investigate the immune checkpoint inhibitors present in the pharmaceutical market, their mechanism of action and mostly about their immune-related adverse events. Being an innovative therapy with such distinct adverse events from those known for other anti-cancerous therapies, makes it important and imperative to try as much as possible to understand the possible reasons for their appearance and the best way to treat them. It was also accomplished an analysis of the principal critical points found in the three guidelines more often used as a work tool in the resolution of the immune-related adverse events. To perform this study, a bibliographic review was accomplished in three scientific databases: PubMed, Scopus and Clarivate Analytics, with the inclusion of articles published in the period between 1st January 2018 and 9th February 2019, being also consulted the Summary of Product Characteristics of each one of the immune checkpoint inhibitors approved by European Medicines Agency (EMA) and U.S. Food and Drug Administration (FDA) until July 2019. The second chapter reflects the professionalizing experience in Hospital Pharmacy which took place in the Pharmaceutical Services of the Local Health Unit of Castelo Branco and the third chapter is about the Community Pharmacy internship made in Farmácia Antunes, in Miranda do Corvo. In this report there are also present the different works shown in congresses and conferences and that intended to make known new perspectives and approaches about this theme.
Description
Keywords
Cancro Efeitos Adversos Imunitários Farmácia Comunitária Farmácia Hospitalar Inibidores dos Checkpoints Imunitários