Logo do repositório
 
Publicação

MicroRNAs in Takotsubo Syndrome: A Systematic Review of Regulatory Networks in Stress-Induced Cardiomyopathy

2025-10-08Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorSousa, Domingos
dc.contributor.authorMartins, Filipa Abreu
dc.contributor.authorLuís, Ângelo
dc.contributor.authorSerralheiro, Pedro
dc.date.accessioned2026-02-06T16:10:11Z
dc.date.available2026-02-06T16:10:11Z
dc.date.issued2025-10-08
dc.description.abstractMicroRNAs (miRNAs) have emerged as crucial regulators of gene expression and have been implicated in various physiological and pathological processes, including cardiovascular diseases. The clinical presentation, diagnostic criteria, and proposed pathophysiological mechanisms of Takotsubo Syndrome (TTS) are discussed, with an emphasis on the emerging evidence implicating miRNAs in its etiology and progression. A systematic review following the PRISMA guidelines was performed on the evidence regarding the interplay between miRNAs and TTS. A search of the Pubmed, Web of Science, and Scopus databases was conducted and resulted in 584 articles. Of these, 14 full-text articles were eligible for inclusion in the qualitative analysis. The reviewed studies suggest that multiple miRNAs are involved in the processes associated with TTS pathophysiology, including acute and chronic myocardial inflammation, oxidative stress, apoptosis, microvascular dysfunction, hypertrophy, and, ultimately, maladaptive cardiac remodelling. This review provides an overview of the current understanding of miRNAs in cardiovascular pathophysiology, with a specific focus on their potential roles in TTS. To the best of our knowledge, this is the first systematic exploration of the miRNAs involved in TTS and its modulation as potential biomarkers or therapeutic targets.eng
dc.identifier.citationSousa, D., Martins, F. A., Luís, Â., & Serralheiro, P. (2025). MicroRNAs in Takotsubo Syndrome: A Systematic Review of Regulatory Networks in Stress-Induced Cardiomyopathy. International Journal of Molecular Sciences, 26(19), 9790. https://doi.org/10.3390/ijms26199790
dc.identifier.doi10.3390/ijms26199790
dc.identifier.issn1422-0067
dc.identifier.other41097055
dc.identifier.urihttp://hdl.handle.net/10400.6/19871
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMicroRNAs
dc.subjectTakotsubo Syndrome
dc.subjectBiomarker
dc.subjectCardiac dysfunction
dc.subjectMyocardial inflammation
dc.subjectMyocardial remodelling
dc.subjectStress-induced cardiomyopathy
dc.titleMicroRNAs in Takotsubo Syndrome: A Systematic Review of Regulatory Networks in Stress-Induced Cardiomyopathypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSousa
person.familyNameMartins
person.familyNameLuís
person.familyNameSerralheiro
person.givenNameDomingos Rocha
person.givenNameFilipa Abreu
person.givenNameÂngelo Filipe Santos
person.givenNamePedro
person.identifier.ciencia-id1912-CFE7-FEA3
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.orcid0000-0001-6657-5921
person.identifier.orcid0000-0003-1385-3902
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-8190-5527
relation.isAuthorOfPublicationc1b6c128-636c-46d6-9e5c-3572348b6056
relation.isAuthorOfPublication94cb2f06-3515-49ee-bfc2-a6d85479d504
relation.isAuthorOfPublicationa2d7c872-99db-41e1-9bc9-82c2d47b4661
relation.isAuthorOfPublicationc5490083-2a1b-4d9b-bba0-a1ad744b9745
relation.isAuthorOfPublication.latestForDiscoveryc1b6c128-636c-46d6-9e5c-3572348b6056

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
ijms-26-09790.pdf
Tamanho:
1.34 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ICI - CICS | Documentos por Auto-Depósito
FCS - DCM | Documentos por Auto-Depósito