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Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

2018-10Journal article Restricted access
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dc.contributor.authorMoreira, André
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorReis, Ana Catarina Almeida
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-12-11T10:05:13Z
dc.date.available2018-12-11T10:05:13Z
dc.date.issued2018-10
dc.description.abstractAim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, A.F., Rodrigues, C.F., Reis. C.A., Costa, E.C., Ferreira, P., Correia, I.J. (2018) "Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy", Nanomedicine, Vol. 13, Nº 20pt_PT
dc.identifier.doi10.2217/nnm-2018-0179pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6609
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Medicinept_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.futuremedicine.com/doi/abs/10.2217/nnm-2018-0179?journalCode=nnmpt_PT
dc.subjectCancerpt_PT
dc.subjectCombinatorial therapypt_PT
dc.subjectDrug-deliverypt_PT
dc.subjectGold-core silica shell nanorodspt_PT
dc.subjectPhotothermal therapypt_PT
dc.titleDevelopment of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.startPage20pt_PT
oaire.citation.titleNanomedicinept_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameFélix Rodrigues
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameAna Carolina
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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