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Advisor(s)
Abstract(s)
Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.
Description
Keywords
Cancer Combinatorial therapy Drug-delivery Gold-core silica shell nanorods Photothermal therapy
Citation
Moreira, A.F., Rodrigues, C.F., Reis. C.A., Costa, E.C., Ferreira, P., Correia, I.J. (2018) "Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy", Nanomedicine, Vol. 13, Nº 20
Publisher
Future Medicine