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Multifunctional Nanocarriers for Co-Delivery of Nucleic Acids and Chemotherapeutics to Cancer Cells

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dc.contributor.authorGaspar, Vítor Manuel Abreu
dc.contributor.authorMoreira, André
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorQueiroz, João
dc.contributor.authorSousa, Fani
dc.contributor.authorPichon, Chantal
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-04-04T08:43:02Z
dc.date.available2018-04-04T08:43:02Z
dc.date.issued2016
dc.description.abstractCombinatorial therapies established on codelivery of drugs and nucleic acids are receiving increased attention due to their outstanding potential for improving cancer therapy in comparison to standalone treatments. This encouraging approach gathers the anticancer activity of chemotherapeutics and nucleic acid capacity to repair deregulated signaling pathways, as a joint strategy to achieve a beneficial anticancer effect. Such coadministration of drugs and genes is, however, remarkably challenging as these therapeutics exhibit distinct physicochemical properties. This chapter outlines the concepts underlying combinatorial therapy and the development of multifunctional nanocarriers specifically designed for codelivery of drug–gene combinations to cancer cells. A particular emphasis is given to key nanocarrier physicochemical properties required for drug–nucleic acid loading, release, and delivery in target organs. Various examples of multifunctional nanobiomaterials employed in multifunctional particle assembly are also discussed. As a final point the perspective of future improvements toward clinical applications are discussed in light of recent advances.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGaspar, V.M., Moreira, A.F., de Melo-Diogo, D., Costa, E.C., Queiroz, J.A., Sousa, F., Pichon, C. e Correia, I.J. (2016) “Multifunctional Nanocarriers for Co-Delivery of Nucleic Acids and Chemotherapeutics to Cancer Cells.” In Grumezescu, A.M. (Ed). Nanobiomaterials of Medical Imaging – Volume VIII, capítulo 6, ISBN: 9780323417365, William Andrew; 2016pt_PT
dc.identifier.doi10.1016/B978-0-323-41736-5.00006-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4734
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B9780323417365000066pt_PT
dc.subjectNanomedicinept_PT
dc.subjectCodeliverypt_PT
dc.subjectNucleic acidspt_PT
dc.subjectDrugspt_PT
dc.subjectCombinatorial cancer therapypt_PT
dc.subjectTheranosticspt_PT
dc.titleMultifunctional Nanocarriers for Co-Delivery of Nucleic Acids and Chemotherapeutics to Cancer Cellspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.titleNanobiomaterials in Medical Imagingpt_PT
person.familyNameGaspar
person.familyNameMoreira
person.familyNameMiguel de Melo Diogo
person.familyNameda Rocha Costa
person.familyNameQueiroz
person.familyNameSousa
person.familyNameJoaquim Sobreira Correia
person.givenNameVítor
person.givenNameAndré Ferreira
person.givenNameDuarte
person.givenNameElisabete Cristina
person.givenNameJoão
person.givenNameFani
person.givenNameIlídio
person.identifier1161643
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person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-9996-2194
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1602-2017
person.identifier.ridL-3104-2014
person.identifier.ridA-2014-2017
person.identifier.scopus-author-id36968590900
person.identifier.scopus-author-id56401521300
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rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
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