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Advisor(s)
Abstract(s)
Combinatorial therapies established on codelivery of drugs and nucleic acids are receiving increased attention due to their outstanding potential for improving cancer therapy in comparison to standalone treatments. This encouraging approach gathers the anticancer activity of chemotherapeutics and nucleic acid capacity to repair deregulated signaling pathways, as a joint strategy to achieve a beneficial anticancer effect. Such coadministration of drugs and genes is, however, remarkably challenging as these therapeutics exhibit distinct physicochemical properties. This chapter outlines the concepts underlying combinatorial therapy and the development of multifunctional nanocarriers specifically designed for codelivery of drug–gene combinations to cancer cells. A particular emphasis is given to key nanocarrier physicochemical properties required for drug–nucleic acid loading, release, and delivery in target organs. Various examples of multifunctional nanobiomaterials employed in multifunctional particle assembly are also discussed. As a final point the perspective of future improvements toward clinical applications are discussed in light of recent advances.
Description
Keywords
Nanomedicine Codelivery Nucleic acids Drugs Combinatorial cancer therapy Theranostics
Citation
Gaspar, V.M., Moreira, A.F., de Melo-Diogo, D., Costa, E.C., Queiroz, J.A., Sousa, F., Pichon, C. e Correia, I.J. (2016) “Multifunctional Nanocarriers for Co-Delivery of Nucleic Acids and Chemotherapeutics to Cancer Cells.” In Grumezescu, A.M. (Ed). Nanobiomaterials of Medical Imaging – Volume VIII, capítulo 6, ISBN: 9780323417365, William Andrew; 2016
Publisher
Elsevier