| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.38 MB | Adobe PDF |
Authors
Abstract(s)
Os problemas associados à prevalência e infecção por fungos do género Candida nos tempos correntes devem ser um tema de grande preocupação e debate na comunidade científica e dos prestadores de cuidados de saúde. A candidose vulvovaginal afeta anualmente milhões de indivíduos à escala global. O panorama traçado em estudos epidemiológicos revela uma tendência crescente na incidência da patologia, sobre a qual versa o presente trabalho. Com a realização deste trabalho de investigação pretendemos contribuir para a identificação das espécies de Candida spp prevalentes em casos de candidose vulvovaginal crónica bem como conhecer a relação da dificuldade do tratamento in vivo com o perfil de suscetibilidade in vitro aos antifúngicos azólicos clássicos. Foram incluídos 118 isolados de casos crónicos de candidose vulvovaginal correspondentes a 48 casos clínicos. Os isolados foram identificados com recurso a cultura em Chromagar ou carta de identificação Vitek® e a sua susceptibilidade aos antifúngicos determinada segundo o método da microdiluição CLSI M27-A3. Como principais resultados temos o aumento da incidência de Candidose Vulvovaginal mediada por espécies não-albicans, verifica-se um aumento das resistências ao fluconazole que é o fármaco de referência no tratamento. Com base nos dados obtidos pode intuir-se a necessidade de novas abordagens e de medidas de prevenção e controlo.
The problems associated to the prevalence and infection by fungi of the gender Candida in current times should be a topic of great concern and debate in the scientific community and health care providers. Vulvovaginal candidiasis affects annually millions of people globally. The panorama outlined in epidemiological studies show an increasing trend in the incidence of pathology on which this paper versa. With the realization of this investigation we intend to contribute to the identification of Candida spp prevalent species in cases of chronic vulvovaginal candidiasis as well as knowing the relationship of the difficulty of in vivo treatment with the profile of in vitro susceptibility to azole antifungals classics. We included 118 isolates from cases of chronic vulvovaginal candidiasis corresponding to 48 clinical cases. The isolates were identified using culture Chromagar medium or identification cards - VITEK® and their susceptibility to antifungal agents was determined by the microdilution method CLSI M27-A3. The main results have showed an increased in the incidence of vulvovaginal candidiasis mediated by non-albicans species, there is an increasing resistance to fluconazole that is the reference drug treatment. Based on the data obtained can intuit the need for new approaches and measures for prevention and control.
The problems associated to the prevalence and infection by fungi of the gender Candida in current times should be a topic of great concern and debate in the scientific community and health care providers. Vulvovaginal candidiasis affects annually millions of people globally. The panorama outlined in epidemiological studies show an increasing trend in the incidence of pathology on which this paper versa. With the realization of this investigation we intend to contribute to the identification of Candida spp prevalent species in cases of chronic vulvovaginal candidiasis as well as knowing the relationship of the difficulty of in vivo treatment with the profile of in vitro susceptibility to azole antifungals classics. We included 118 isolates from cases of chronic vulvovaginal candidiasis corresponding to 48 clinical cases. The isolates were identified using culture Chromagar medium or identification cards - VITEK® and their susceptibility to antifungal agents was determined by the microdilution method CLSI M27-A3. The main results have showed an increased in the incidence of vulvovaginal candidiasis mediated by non-albicans species, there is an increasing resistance to fluconazole that is the reference drug treatment. Based on the data obtained can intuit the need for new approaches and measures for prevention and control.
Description
Keywords
Candida Spp. Candidíase Vulvovaginal Clotrimazol Fluconazol Resistência Suscetibilidade