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Regulation of human umbilical artery contractility by different serotonin and histamine receptors

2009Journal article Open access
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dc.contributor.authorVerde, Ignacio
dc.contributor.authorSilva, António José Santos
dc.contributor.authorCairrão, Elisa
dc.contributor.authorMarques, Brunopt
dc.date.accessioned2010-04-28T10:06:46Z
dc.date.available2010-04-28T10:06:46Z
dc.date.issued2009
dc.description.abstractWe studied the role of several serotonin (5-HT) and histamine receptors in the regulation of human umbilical artery (HUA) contractility. Among the 5-HT agonists used, only the 5-HT2A and 5HT1B/D agonists contracts HUA. The 5-HT-induced contractions were fully inhibited by ketanserin (5-HT2A antagonist). The 5-HT7-activation also relaxes and increases intracellular cyclic adenosine monophosphate (cAMP). Among the histamine receptor agonists, only betahistine (H1 agonist) induced significant contractile effect. Histamine-induced contraction was partially relaxed by pyrilamine (H1 antagonist). Betahistine-induced contraction was partially blocked by dimaprit (H2 agonist) and by the H3 agonist when a low concentration of forskolin is present. Both, H2 and H3 agonists increased the cAMP intracellular levels in HUA smooth muscle. These findings show that in HUA, 5-HT2A- and 5-HT1B/1D-activation lead to vasoconstriction and 5-HT7-activation induces vasorelaxation. Concerning histamine receptors, H1-activation induces contraction and H2- and H 3-activation lead to vasorelaxation.
dc.identifier.urihttp://hdl.handle.net/10400.6/546
dc.language.isoengpt
dc.titleRegulation of human umbilical artery contractility by different serotonin and histamine receptorspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6: 1175-85pt
oaire.citation.titleReprod Scipt
person.familyNameVerde
person.familyNameSantos-Silva AJ
person.familyNameCairrao Rodrigues Oliveira
person.givenNameIgnacio
person.givenNameAntónio José dos Santos Silva
person.givenNameMaria Elisa
person.identifierAAB-1164-2020
person.identifier.ciencia-idD012-1D7C-791A
person.identifier.ciencia-id0611-71B8-191E
person.identifier.orcid0000-0003-3492-5725
person.identifier.orcid0000-0002-8200-1052
person.identifier.orcid0000-0002-4823-5701
person.identifier.ridM-3991-2013
person.identifier.scopus-author-id55913729400
person.identifier.scopus-author-idScopus Author ID: 23476537500
rcaap.rightsopenAccesspt
rcaap.typearticlept
relation.isAuthorOfPublicationbfb58284-b817-4267-9628-8fa150aa681c
relation.isAuthorOfPublication211cd7f0-41c8-4799-874d-a94f3f0385cd
relation.isAuthorOfPublication2718c108-c03e-44a3-98a7-b05366e0fe61
relation.isAuthorOfPublication.latestForDiscoverybfb58284-b817-4267-9628-8fa150aa681c

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