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Polyazamacrocycles as potential antitumor agents for human prostate cancer cells

2013-04Journal article Restricted access
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dc.contributor.authorCruz, Carla
dc.contributor.authorCairrão, Elisa
dc.contributor.authorLourenço, Olga
dc.contributor.authorAlmeida, Paulo
dc.contributor.authorVerde, Ignacio
dc.contributor.authorQueiroz, João
dc.date.accessioned2020-02-18T17:06:00Z
dc.date.available2020-02-18T17:06:00Z
dc.date.issued2013-04
dc.description.abstractPolyazamacrocycles are currently being studied and used in a variety of applications beyond their traditional place in supramolecular and co-ordination chemistry. This study suggests additional applications of these compounds with particular emphasis on their use as antiproliferative agents that could be potentially used to treat cancer. Four polyazamacrocycles were tested in human prostate cancer LNCaP and prostate epithelial PNTA1 cells to analyze changes in cell proliferation and cell death capabilities. Their intracellular localization was also evaluated by confocal microscopy. The results show a decrease in proliferation rate and cell viability of LNCaP and PNTA1, after treatment with these compounds. The decrease in the number of viable cells is similar for the majority of the compounds studied, and at higher concentration, the proliferation efficiency decreased significantly in the cell lines studied. Also, our results suggest that L and L2 induce early apoptosis in PNTA1 cells and late apoptosis/necrosis in LNCaP cells. The compounds did not induce a significant increase in necrosis of both cell types. Although the compounds did not localize in a unique organelle, all of them have as main target the Golgi apparatus and other localization profiles differed depending on the cell line.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1111/cbdd.12098pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9351
dc.language.isoengpt_PT
dc.relationAffinity Interactions between Cyanine Dyes and Biomolecules in Chromatographic Processes
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationStrategic Project - UI 709 - 2011-2012
dc.subjectAntineoplastic Agentspt_PT
dc.subjectAza Compoundspt_PT
dc.subjectCell Linept_PT
dc.subjectCell Proliferationpt_PT
dc.subjectHumanspt_PT
dc.subjectMacrocyclic Compoundspt_PT
dc.subjectMalept_PT
dc.subjectMicroscopy Fluorescencept_PT
dc.subjectProstatic Neoplasmspt_PT
dc.titlePolyazamacrocycles as potential antitumor agents for human prostate cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAffinity Interactions between Cyanine Dyes and Biomolecules in Chromatographic Processes
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F46934%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FQUI-QUI%2F100896%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.citation.endPage526pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage517pt_PT
oaire.citation.titleChemical Biology and Drug Designpt_PT
oaire.citation.volume81pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6820 - DCRRNI ID
person.familyNameCruz
person.familyNameCairrao Rodrigues Oliveira
person.familyNameLourenço
person.familyNameAlmeida
person.familyNameVerde
person.familyNameQueiroz
person.givenNameCarla
person.givenNameMaria Elisa
person.givenNameOlga Maria Marques
person.givenNamePaulo
person.givenNameIgnacio
person.givenNameJoão
person.identifierAAB-1164-2020
person.identifier.ciencia-id6816-7888-F8B1
person.identifier.ciencia-id0611-71B8-191E
person.identifier.ciencia-id6618-1C4C-D1B7
person.identifier.ciencia-id6E18-3C6F-6842
person.identifier.ciencia-idD012-1D7C-791A
person.identifier.ciencia-id931E-B66D-E341
person.identifier.orcid0000-0001-6630-1242
person.identifier.orcid0000-0002-4823-5701
person.identifier.orcid0000-0002-8401-5976
person.identifier.orcid0000-0003-0110-4795
person.identifier.orcid0000-0003-3492-5725
person.identifier.orcid0000-0002-3096-8325
person.identifier.ridI-7806-2013
person.identifier.ridA-1600-2014
person.identifier.ridM-3991-2013
person.identifier.ridL-3104-2014
person.identifier.scopus-author-id7202701394
person.identifier.scopus-author-idScopus Author ID: 23476537500
person.identifier.scopus-author-id7102848111
person.identifier.scopus-author-id55913729400
person.identifier.scopus-author-id7003705645
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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