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The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies

2020Journal article Open access
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dc.contributor.authorLuís, Ângelo
dc.contributor.authorMarcelino, Helena
dc.contributor.authorRosa, Carolina
dc.contributor.authorDomingues, F.C.
dc.contributor.authorPereira, L.
dc.contributor.authorCascalheira, José
dc.date.accessioned2020-03-30T16:12:44Z
dc.date.available2020-03-30T16:12:44Z
dc.date.issued2020
dc.description.abstractGlioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the efficacy of cannabinoids in animal models of GBM have been described, but the diversity of experimental conditions and of outcomes hindered definitive conclusions about cannabinoids efficacy. A search in different databases (Pubmed, Web of Science, Scopus and SciELO) was conducted during June 2019 to systematically identify publications evaluating the effects of cannabinoids in murine xenografts models of GBM. The tumour volume and number of animals were extracted, and a random effects meta-analysis of these results was performed to estimate the efficacy of cannabinoids. The impact of different experimental factors and publication bias on the efficacy of cannabinoids was also assessed. Nine publications, which satisfied the inclusion criteria, were identified and subdivided in 22 studies involving 301 animals. Overall, cannabinoid therapy reduced the fold of increase in tumour volume in animal models of GBM, when compared with untreated controls. The overall weighted standardized difference in means (WSDM) for the effect of cannabinoids was -1.399 (95% CI: -1.900 to -0.898; P-value<0.0001). Furthermore, treatment efficacy was observed for different types of cannabinoids, alone or in combination, and for different treatment durations. Cannabinoid therapy was still effective after correcting for publication bias. The results indicate that cannabinoids reduce the tumour growth in animal models of GBM, even after accounting for publication bias.pt_PT
dc.description.sponsorshipOperação Centro-01-0145-FEDER-000019-C4-Centro de Competências em Cloud Computingpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejphar.2020.173055pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10252
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.subjectAnimal model studiespt_PT
dc.subjectCannabinoidspt_PT
dc.subjectGlioblastoma multiformept_PT
dc.subjectMeta-Analysispt_PT
dc.subjectSystematic reviewpt_PT
dc.titleThe effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIM-ONC%2F7121%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.startPage173055pt_PT
oaire.citation.titleEuropean Journal of Pharmacologypt_PT
oaire.citation.volume876pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLuís
person.familyNameMarcelino
person.familyNameBoialvo Rosa
person.familyNameDomingues
person.familyNamePereira
person.familyNameda Silva Cascalheira
person.givenNameÂngelo Filipe Santos
person.givenNameHelena
person.givenNameCarolina
person.givenNameFernanda
person.givenNameLuísa
person.givenNameJosé Francisco
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-idF812-63AE-07C6
person.identifier.ciencia-id6514-0498-3E8F
person.identifier.ciencia-id4F15-1868-D001
person.identifier.ciencia-idB219-078D-FD06
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0002-6218-6192
person.identifier.orcid0000-0002-4684-5661
person.identifier.orcid0000-0002-9540-0853
person.identifier.orcid0000-0002-9068-4607
person.identifier.orcid0000-0002-5315-3866
person.identifier.ridE-7661-2015
person.identifier.ridN-7295-2013
person.identifier.scopus-author-id35080864400
person.identifier.scopus-author-id10139481400
person.identifier.scopus-author-id10839238300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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