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Estudo dos efeitos a nível celular da exposição do Dibutil Ftalato (DBP) em materiais plásticos de uso hospitalar
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| Documento em Acesso Embargado até dia 13-10-2028. Tente solicitar cópia ao autor carregando no ficheiro | 3.69 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Com o avanço incessante da tecnologia, os plásticos tornaram-se uma presença constante no nosso quotidiano, trazendo consigo compostos químicos que representam riscos significativos, uma vez que atuam como perigosos disruptores endócrinos (DEs). Estas substâncias comprometem silenciosamente a nossa qualidade de vida à medida que a industrialização avança. Um dos quais se destaca como particularmente preocupante é o Di-n-butil Ftalato (DBP), um composto sintético classificado como um éster de ácido ftálico de baixo peso molecular. A sua principal utilização consiste em conferir flexibilidade e maleabilidade a polímeros, nomeadamente ao cloreto de polivinilo e látex. Posto isto, o DBP destaca-se em inúmeras aplicações, incluindo produtos de puericultura, artigos de higiene pessoal, produtos cosméticos e em materiais e dispositivos médicos, imprescindíveis nos serviços de saúde. Dado o seu impacto, é urgente reavaliar a sua presença nas vertentes médicas, a fim de eliminar fontes potenciais de exposição a este agente. O DBP está inegavelmente associado a problemas de saúde graves, incluindo alterações metabólicas, dislipidemias, disfunção sexual, efeitos adversos durante a gravidez, bem como consequências negativas para a saúde de lactantes, além de apresentar um risco significativo para os sistemas hepático e urinário. O presente estudo defende a necessidade de reavaliar os danos provocados pelo DBP nos vários sistemas do organismo, com especial ênfase nos seus efeitos sobre a saúde cardiovascular e na sua associação com doenças vasculares, como a aterosclerose. Por conseguinte, desenvolveu-se uma avaliação dos mecanismos de cardiotoxicidade induzidos pelo DBP, destacando o impacto crítico que este composto provoca no desenvolvimento do sistema cardiovascular. Além disso, analisou-se e discutiu-se a acumulação de respostas tóxicas desencadeadas por este composto sintético, que comprometem gravemente a saúde cardíaca, com particular foco em pacientes que permanecem hospitalizados, ou em unidades de cuidados por longos períodos.
With the relentless advancement of technology, plastics have become a constant presence in our daily lives, bringing with them chemical compounds that pose significant risks, as they act as dangerous endocrine disruptors (EDs). These substances silently compromise our quality of life as industrialization advances. One of particular concern is Di-n-butyl Phthalate (DBP), a synthetic compound classified as a low molecular weight phthalic acid ester. Its main use is to impart flexibility and malleability to polymers, namely polyvinyl chloride and latex. That said, DBP stands out in numerous applications, including childcare products, personal hygiene items, cosmetics, and medical materials and devices, which are essential in healthcare services. Given its impact, it is urgent to reassess its presence in medical settings in order to eliminate potential sources of exposure to this agent. DBP is undeniably associated with serious health problems, including metabolic changes, dyslipidemia, sexual dysfunction, adverse effects during pregnancy, as well as negative consequences for the health of infants, in addition to posing a significant risk to the hepatic and urinary systems. This study argues for the need to reassess the damage caused by DBP in various body systems, with particular emphasis on its effects on cardiovascular health and its association with vascular diseases such as atherosclerosis. Therefore, an assessment of the cardiotoxicity mechanisms induced by DBP was developed, highlighting the critical impact this compound has on the development of the cardiovascular system. In addition, the accumulation of toxic responses triggered by this synthetic compound, which seriously compromise cardiac health, was analyzed and discussed, with a particular focus on patients who remain hospitalized or in care units for long periods.
With the relentless advancement of technology, plastics have become a constant presence in our daily lives, bringing with them chemical compounds that pose significant risks, as they act as dangerous endocrine disruptors (EDs). These substances silently compromise our quality of life as industrialization advances. One of particular concern is Di-n-butyl Phthalate (DBP), a synthetic compound classified as a low molecular weight phthalic acid ester. Its main use is to impart flexibility and malleability to polymers, namely polyvinyl chloride and latex. That said, DBP stands out in numerous applications, including childcare products, personal hygiene items, cosmetics, and medical materials and devices, which are essential in healthcare services. Given its impact, it is urgent to reassess its presence in medical settings in order to eliminate potential sources of exposure to this agent. DBP is undeniably associated with serious health problems, including metabolic changes, dyslipidemia, sexual dysfunction, adverse effects during pregnancy, as well as negative consequences for the health of infants, in addition to posing a significant risk to the hepatic and urinary systems. This study argues for the need to reassess the damage caused by DBP in various body systems, with particular emphasis on its effects on cardiovascular health and its association with vascular diseases such as atherosclerosis. Therefore, an assessment of the cardiotoxicity mechanisms induced by DBP was developed, highlighting the critical impact this compound has on the development of the cardiovascular system. In addition, the accumulation of toxic responses triggered by this synthetic compound, which seriously compromise cardiac health, was analyzed and discussed, with a particular focus on patients who remain hospitalized or in care units for long periods.
Descrição
Palavras-chave
Di-n-butil Ftalato Dispositivos médicos Disruptores endócrinos Sistema cardiovascular Cardiotoxicidade Exposição crónica Exposição materno-fetal Medical devices Endocrine disruptors Cardiovascular system Cardiotoxicity Cronic exposure Maternal-fetal exposure