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Development of a new chitosan hydrogel for wound dressing

2009Journal article Open access
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dc.contributor.authorRibeiro, MP.
dc.contributor.authorEspiga, Anapt
dc.contributor.authorSilva, Danielapt
dc.contributor.authorBaptista, Patríciapt
dc.contributor.authorHenriques, Joaquim
dc.contributor.authorFerreira, Catarina L.
dc.contributor.authorSilva, Jorge C.pt
dc.contributor.authorBorges, João P.pt
dc.contributor.authorPires, Eduardopt
dc.contributor.authorChaves, Paula
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2010-04-28T10:07:28Z
dc.date.available2010-04-28T10:07:28Z
dc.date.issued2009
dc.description.abstractWound healing is a complex process involving an integrated response by many different cell types and growth factors in order to achieve rapid restoration of skin architecture and function. The present study evaluated the applicability of a chitosan hydrogel (CH) as a wound dressing. Scanning electron microscopy analysis was used to characterize CH morphology. Fibroblast cells isolated from rat skin were used to assess the cytotoxicity of the hydrogel. CH was able to promote cell adhesion and proliferation. Cell viability studies showed that the hydrogel and its degradation by-products are noncytotoxic. The evaluation of the applicability of CH in the treatment of dermal burns in Wistar rats was performed by induction of full-thickness transcutaneous dermal wounds. Wound healing was monitored through macroscopic and histological analysis. From macroscopic analysis, the wound beds of the animals treated with CH were considerably smaller than those of the controls. Histological analysis revealed lack of a reactive or a granulomatous inflammatory reaction in skin lesions with CH and the absence of pathological abnormalities in the organs obtained by necropsy, which supported the local and systemic histocompatibility of the biomaterial. The present results suggest that this biomaterial may aid the re-establishment of skin architecture.pt
dc.identifier.urihttp://hdl.handle.net/10400.6/618
dc.languagepor
dc.subjectBiocompatibilitypt
dc.subjectBiodegradablept
dc.subjectCell adhesionpt
dc.subjectChitosan Hydrogelpt
dc.subjectWound healingpt
dc.titleDevelopment of a new chitosan hydrogel for wound dressingpt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt
oaire.citation.titleWound Repair and Regenerationpt
person.familyNameRibeiro
person.familyNameGarcia Pereira Henriques
person.familyNameProença Valente Ferreira
person.familyNameChaves
person.familyNameJoaquim Sobreira Correia
person.givenNameMaximiano
person.givenNameJoaquim José
person.givenNameCatarina da Luz
person.givenNamePaula
person.givenNameIlídio
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-id3012-4004-172B
person.identifier.ciencia-id0A13-9603-4FC2
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0002-2293-2277
person.identifier.orcid0000-0002-6858-2604
person.identifier.orcid0000-0002-0732-2059
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003558877
person.identifier.scopus-author-id7003557499
rcaap.rightsopenAccess
rcaap.typearticlept
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