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Abstract(s)
O eixo intestino-cérebro tem sido descrito como importante para várias funções
cerebrais e tem sido o foco de diversos estudos nos últimos anos na área das doenças
neurodegenerativas. Na doença de Parkinson, as manifestações gastrointestinais podem
antecipar os sintomas motores em vários anos e tem sido demonstrada a existência de um
desequilíbrio da microbiota intestinal em doentes afetados por esta patologia. A abundância
relativa de determinados géneros bacterianos assim como o aumento da permeabilidade e
da inflamação intestinal encontrada têm reforçado a hipótese de se encontrar a
etiopatogenia da doença no estudo das comunidades microbianas que habitam no intestino.
A descoberta de biomarcadores fecais pode permitir um diagnóstico mais precoce da doença
e novas terapias dirigidas à regulação da microbiota intestinal podem ser a chave do
controlo de sintomas motores e não motores da doença. O estudo do eixo intestino-cérebro
e a intervenção na microbiota intestinal podem ser possibilidades no futuro no que toca à
gestão da doença de Parkinson e de outras doenças neurodegenerativas, que até à data não
possuem tratamentos que possam retardar ou deter a sua progressão.
The gut-brain axis has been described as important for various brain functions and has been, recently, the focus of several studies in neurodegenerative diseases. In Parkinson's disease, gastrointestinal manifestations can anticipate motor symptoms in several years and an imbalance of the intestinal microbiota has been demonstrated in patients affected by this pathology. The relative abundance of certain bacterial genera as well as the increased permeability and intestinal inflammation found have reinforced the hypothesis of finding the etiopathogenesis of the disease in the study of microbial communities inhabiting the intestine. The discovery of fecal biomarkers may allow an earlier diagnosis of the disease and new therapies aimed at regulating the intestinal microbiota may be the key to control motor and non-motor symptoms of the disease. The study of the gut-brain axis and the intervention in the intestinal microbiota may be possibilities in the future to the management of Parkinson's disease and other neurodegenerative diseases, which do not have treatments that can slow or stop their progression yet.
The gut-brain axis has been described as important for various brain functions and has been, recently, the focus of several studies in neurodegenerative diseases. In Parkinson's disease, gastrointestinal manifestations can anticipate motor symptoms in several years and an imbalance of the intestinal microbiota has been demonstrated in patients affected by this pathology. The relative abundance of certain bacterial genera as well as the increased permeability and intestinal inflammation found have reinforced the hypothesis of finding the etiopathogenesis of the disease in the study of microbial communities inhabiting the intestine. The discovery of fecal biomarkers may allow an earlier diagnosis of the disease and new therapies aimed at regulating the intestinal microbiota may be the key to control motor and non-motor symptoms of the disease. The study of the gut-brain axis and the intervention in the intestinal microbiota may be possibilities in the future to the management of Parkinson's disease and other neurodegenerative diseases, which do not have treatments that can slow or stop their progression yet.
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Keywords
Disbiose Intestinal Doença de Parkinson Eixo Intestino-Cérebro Microbiota Intestinal