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T cells in sputum of asthmatic patients are activated independently of disease severity or control

2009Journal article Open access
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dc.contributor.authorLourenço, Olga
dc.contributor.authorFonseca, A. M.
dc.contributor.authorBarata, Luis Taborda
dc.date.accessioned2019-12-19T16:01:44Z
dc.date.available2019-12-19T16:01:44Z
dc.date.issued2009
dc.description.abstractBackground T cells play an important role in bronchial asthma. Although airway CD4+ T cells have been extensively studied previously, there are hardly any studies relating CD8+ T cell activation and disease symptoms. Objectives The aim of this study was to analyse the association between T cell activation in induced sputum T cells and asthma severity and control; and to evaluate T cell subpopulations in the same subgroups. Methods Fifty allergic asthmatic patients were recruited and lung function testing was performed. Airway cells were obtained by sputum induction via inhalation of hypertonic saline solution. CD3, CD4, CD8, CD28, CD25 and CD69 were studied by flow cytometry in whole induced sputum and peripheral blood cells. Results Total induced sputum T cells and CD8+ T cells had a higher relative percentage of the activation markers CD25 and CD69 in comparison with peripheral blood. In sputum, the relative percentage of CD25 was higher in CD4+ T cells when compared to CD8+ T cells and the reverse was true regarding CD69. However, neither disease severity nor control were associated with the relative percentage of CD25 or CD69 expression on T cells in sputum. Conclusions Both CD4+ and CD8+ T cells are activated in the lungs and peripheral blood of asthmatic patients. However, with the possible exception of CD69+ CD8+ T lymphocytes in the sputum, there is no association between T cell activation phenotype in the target organ and disease severity or control.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.aller.2009.05.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7995
dc.language.isoengpt_PT
dc.subjectAsthmapt_PT
dc.subjectT cells - CD25pt_PT
dc.subjectT cells - CD69pt_PT
dc.subjectT cells - CD28pt_PT
dc.subjectSputumpt_PT
dc.subjectT cellspt_PT
dc.titleT cells in sputum of asthmatic patients are activated independently of disease severity or control
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage292pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage285pt_PT
oaire.citation.titleAllergologia et Immunopathologiapt_PT
oaire.citation.volume37pt_PT
person.familyNameLourenço
person.familyNameLoureiro Fonseca
person.familyNameTaborda Barata
person.givenNameOlga
person.givenNameAna Mafalda
person.givenNameLuis
person.identifierH-3836-2012
person.identifier104007
person.identifier.ciencia-id6618-1C4C-D1B7
person.identifier.ciencia-idA61D-657A-6DD0
person.identifier.ciencia-id1E1F-8A43-055B
person.identifier.orcid0000-0002-8401-5976
person.identifier.orcid0000-0003-1118-5525
person.identifier.orcid0000-0001-6649-8890
person.identifier.scopus-author-id15128160500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc890c74a-abc1-4910-aa70-f0da7b4ad902
relation.isAuthorOfPublication34cfbd2d-5537-4aba-8552-3e2e4d48b473
relation.isAuthorOfPublication3f1ad371-56e3-4fda-9409-748e355a0de1
relation.isAuthorOfPublication.latestForDiscoveryc890c74a-abc1-4910-aa70-f0da7b4ad902

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