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Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy

2018-07-24Journal article Restricted access
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dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorAlves, Cátia
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorFerreira, Paula
dc.contributor.authorLouro, Ricardo
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-08-23T09:05:15Z
dc.date.available2018-08-23T09:05:15Z
dc.date.issued2018-07-24
dc.description.abstractReduced graphene oxide (rGO) nanomaterials display promising properties for application in cancer photothermal therapy (PTT). rGO is usually obtained by treating graphene oxide (GO) with hydrazine hydrate. However, this reducing agent contributes for the low cytocompatibility exhibited by rGO. Furthermore, rGO has a low water stability and does not show selectivity towards cancer cells. Herein, rGO attained using an environmentally-friendly method was functionalized with a novel hyaluronic acid (HA)-based amphiphilic polymer to be used in targeted cancer PTT. Initially, the green-reduction of GO with L-Ascorbic acid was optimized considering the near infrared absorption and the size distribution of the nanomaterials. Then, rGO was functionalized with the HA-based amphiphile. The functionalization of rGO improved its stability, cytocompatibility and internalization by CD44 overexpressing cells, which indicates the targeting capacity of this nanoformulation. Furthermore, the on-demand PTT mediated by HA-functionalized rGO induced cancer cells’ ablation, thereby confirming its potential for targeted cancer therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSousa, R. L., de Melo-Diogo, D., Alves, C. G., Costa, E. C., Ferreira, P., Louro, R. O., Correia, I.J. (2018) "Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy", Carbohydrate Polymers, Vol. 200, pp. 93-99.pt_PT
dc.identifier.doi10.1016/j.carbpol.2018.07.066pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/5684
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861718308580pt_PT
dc.subject2D materialspt_PT
dc.subjectTargeted therapypt_PT
dc.subjectPhotothermal effectpt_PT
dc.subjectHyaluronanpt_PT
dc.subjectGreen chemistrypt_PT
dc.titleHyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.endPage99pt_PT
oaire.citation.startPage93pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume200pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSousa
person.familyNameMiguel de Melo Diogo
person.familyNameAlves
person.familyNameda Rocha Costa
person.familyNameLouro
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Rita Lima
person.givenNameDuarte
person.givenNameCátia Gomes
person.givenNameElisabete Cristina
person.givenNameRicardo
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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