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Effects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysis

2021Journal article Open access
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dc.contributor.authorFeijó, Mariana
dc.contributor.authorMartins, Roberta VL
dc.contributor.authorSocorro, Sílvia
dc.contributor.authorPereira, L.
dc.contributor.authorCorreia, Sara
dc.date.accessioned2025-02-19T17:42:49Z
dc.date.available2025-02-19T17:42:49Z
dc.date.issued2021
dc.description.abstractEndocrine-disrupting chemicals have become an issue of scientific and public discussion. Vinclozolin (VNZ) is a fungicide that competitively antagonizes the binding of natural androgens to their receptor, disturbing the function of tissues that are sensitive to these hormones, as is the case of the male reproductive organs. A systematic review with meta-analyses of rodent studies was conducted to answer the following question: Does exposure to VNZ affect sperm parameters and testicular/epididymal weight? The methodology was prespecified according to the Cochrane Handbook for Systematic Reviews and PRISMA recommendations. Sixteen articles met the inclusion criteria, comprising a total of 1189 animals. The risk of publication bias was assessed using the Trim and Fill adjustment, funnel plot, and Egger regression test. Heterogeneity and inconsistency across the findings were tested using the Q-statistic and I2 of Higgins, respectively. Sensitivitywas also analyzed. Statistical analysiswas performed on Comprehensive Meta-Analysis software (Version 2.0), using random models and weighted mean differences along with a 95% confidence interval. Sperm motility, counts, daily sperm production (evidence of publication bias), and epididymis weight were decreased in VNZ-treated animals. Exposure length and dose, as well as the time point of exposure, influenced the obtained results. Despite the moderate/high heterogeneity observed, the sensitivity analysis overall demonstrated the robustness of the findings. The quality scores of the included studies were superior to 4 in a total of 9, then classified as good. The obtained data corroborate the capability of VNZ exposure to disrupt spermatogenic output and compromise male fertility.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1093/biolre/ioab018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/15109
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.subjectEndocrine disruptorspt_PT
dc.subjectVinclozolinpt_PT
dc.subjectSpermpt_PT
dc.titleEffects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.endPage975pt_PT
oaire.citation.startPage962pt_PT
oaire.citation.titleBiology of Reproductionpt_PT
oaire.citation.volume104pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePombal Feijó
person.familyNameLopes Martins
person.familyNameSocorro
person.familyNamePereira
person.familyNameCorreia
person.givenNameMariana
person.givenNameRoberta Vanessa
person.givenNameSílvia Cristina da Cruz Marques
person.givenNameLuísa
person.givenNameSara
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-idFC1F-F519-8104
person.identifier.ciencia-idE910-3C4A-977E
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.ciencia-id4F15-1868-D001
person.identifier.ciencia-id7518-7FBC-A42F
person.identifier.orcid0000-0002-5330-5276
person.identifier.orcid0000-0001-8181-488X
person.identifier.orcid0000-0002-9068-4607
person.identifier.orcid0000-0001-9199-8360
person.identifier.scopus-author-id23097994600
person.identifier.scopus-author-id10839238300
person.identifier.scopus-author-id7004157751
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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