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Vascular mechanisms of testosterone: the non-genomic point of view

2020-02-01Journal article Open access
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dc.contributor.authorLorigo, Margarida
dc.contributor.authorMariana, Melissa
dc.contributor.authorLemos, Manuel C.
dc.contributor.authorCairrão, Elisa
dc.date.accessioned2020-02-12T09:48:30Z
dc.date.available2020-02-12T09:48:30Z
dc.date.issued2020-02-01
dc.description.abstractTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may be related to the interaction with protein/receptor/ion channels of the plasma membrane. The key T effect at the vascular level is vasorelaxation, which is primarily due to its rapid effect. Thus, the main purpose of this review is to discuss the T non-genomic effects at the vascular level and the molecular pathways involved in its vasodilator effect observed in in vivo and in vitro studies. In this sense, the nuclear receptor activation, the influence of vascular endothelium and the activation or inhibition of ion channels (potassium and calcium channels, respectively) will be reviewed regarding all the data that corroborated or not. Moreover, this review also provides a brief update on the association of T with the risk factors for cardiovascular diseases, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia, and hypertension. In summary, in this paper we consider the non-genomic vascular mode of action of androgen in physiological conditions and the main risk factors for cardiovascular diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jsbmb.2019.105496pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9223
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTestosteronept_PT
dc.subjectVasorelaxationpt_PT
dc.subjectAndrogen receptorpt_PT
dc.subjectVascular endotheliumpt_PT
dc.subjectIon channelspt_PT
dc.subjectCardiovascular diseasespt_PT
dc.titleVascular mechanisms of testosterone: the non-genomic point of viewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.startPage105496pt_PT
oaire.citation.titleThe Journal of steroid biochemistry and molecular biologypt_PT
oaire.citation.volume196pt_PT
oaire.fundingStream5876
person.familyNameLorigo
person.familyNameMariana
person.familyNameLemos
person.familyNameCairrao Rodrigues Oliveira
person.givenNameMargarida
person.givenNameMelissa
person.givenNameManuel
person.givenNameMaria Elisa
person.identifierAAB-1164-2020
person.identifier.ciencia-id9517-3DD1-8A12
person.identifier.ciencia-id0410-064E-0400
person.identifier.ciencia-id4B16-606C-8760
person.identifier.ciencia-id0611-71B8-191E
person.identifier.orcid0000-0002-4752-6398
person.identifier.orcid0000-0003-1875-0144
person.identifier.orcid0000-0001-9326-8900
person.identifier.orcid0000-0002-4823-5701
person.identifier.ridD-9861-2013
person.identifier.scopus-author-id57189263496
person.identifier.scopus-author-id35496279500
person.identifier.scopus-author-idScopus Author ID: 23476537500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1cc297f2-7420-4983-984f-e8599829e0e9
relation.isAuthorOfPublication2b422136-d551-44cf-acac-7fb1a83f47a4
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relation.isAuthorOfPublication.latestForDiscovery2718c108-c03e-44a3-98a7-b05366e0fe61
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