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Advisor(s)
Abstract(s)
Os acidentes vasculares cerebrais são uma das principais causas de morbi-mortalidade nos países desenvolvidos sendo uma realidade com graves consequências médicas, sociais e económicas. Vários estudos relatam o importante papel das hormonas sexuais na incidência e resposta biológica do organismo a esta patologia pelo que se torna crucial compreender quais as consequências que a disfunção destes eixos pode ter na mesma.
Objectivos: Rever o papel dos estrogénios e androgénios na etiopatogenia do AVC; Rever o papel da epigenética na etiopatogenia do AVC; Rever o conceito de disruptor endócrino e o seu potencial papel na saúde e na doença; Rever o papel dos disruptores endócrinos na etiopatogenia do AVC, quer a nível da desregulação hormonal quer a nível do seu impacto epigenético.
Metodologia: Leitura e análise de artigos publicados acerca do tema, nos últimos 5 anos, na base de dados do site pubmed.com.
Stroke is one of the major causes of mobility and mortality in developed countries having severe medical, social and economic consequences. Several studies correlate the level of sexual hormones with the incidence of vascular disease and with the biological response after stroke. Therefore it’s crucial to understand how disruption of hormonal homeostasis can influence the pathophysiology of this disease. Objectives: Review the role of estrogens and androgens in stroke pathophysiology; Review the role of epigenetics in stroke pathophysiology; Review the endocrine receptor concept and its role in health and disease; Review the role of endocrine disruptors in stroke pathophysiology, concerning its contribution to hormonal deregulation and its epigenetic impact. Methodology: Reading and analysis of articles concerning this theme, of the last 5 years, in pubmed.com database.
Stroke is one of the major causes of mobility and mortality in developed countries having severe medical, social and economic consequences. Several studies correlate the level of sexual hormones with the incidence of vascular disease and with the biological response after stroke. Therefore it’s crucial to understand how disruption of hormonal homeostasis can influence the pathophysiology of this disease. Objectives: Review the role of estrogens and androgens in stroke pathophysiology; Review the role of epigenetics in stroke pathophysiology; Review the endocrine receptor concept and its role in health and disease; Review the role of endocrine disruptors in stroke pathophysiology, concerning its contribution to hormonal deregulation and its epigenetic impact. Methodology: Reading and analysis of articles concerning this theme, of the last 5 years, in pubmed.com database.
Description
Keywords
Acidente Vascular Cerebral Disruptores Endócrinos Etiopatogenia Hormonas Sexuais