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Abstract(s)
Esta dissertação encontra-se dividida em dois capítulos: o primeiro visa apresentar o
trabalho de investigação realizado no Centro de Investigação em Ciências da Saúde da
Universidade da Beira Interior (CICS-UBI), o segundo é dedicado à experiência
profissionalizante em Farmácia Comunitária.
O Capítulo I baseia-se na investigação desenvolvida no CICS-UBI, sob orientação da
Professora Doutora Elisa Cairrão durante o último ano.
Segundo a Sociedade Europeia de Endocrinologia, os disruptores endócrinos (DEs) são
agentes químicos que mimetizam, bloqueiam ou interferem com os sistemas hormonais
naturais e os seus efeitos na saúde podem perdurar para toda a vida e até ter
consequências em gerações futuras. O Diclofenac é conhecido pelos seus efeitos como
analgésico e anti-inflamatório, sendo usado largamente em diversas condições, tanto
agudas como crónicas, e consequentemente é um dos fármacos mais encontrados no
ambiente aquático, tendo-se verificado o seu efeito de disruptor endócrino em certas
espécies de peixes.
O objetivo do presente estudo era avaliar o efeito do Diclofenac (DCF) como disruptor
endócrino na artéria umbilical humana (AUH). Mediante a utilização de um banho de
órgãos, onde foi estudada a resposta contrátil da artéria, perante a ação de diversos
agentes contráteis. Posteriormente, aplicaram-se concentrações cumulativas de
diclofenac e mediram-se as diferenças de tensão sobre as artérias através transdutores
isométricos. Com a análise dos resultados, verificou-se um maior relaxamento das
artérias com o aumento das concentrações de Diclofenac, sendo este efeito mais visível
quando sujeitas ao agente contrátil histamina. Porém, são necessários mais estudos
futuros para compreender o mecanismo exato deste agente na contratilidade vascular
em humanos, em particular na população gravídica.
No capítulo II resume-se a experiência e aprendizagem obtida durante o estágio na
Farmácia Moderna, no Tortosendo, entre 1 de março e 15 de julho de 2021, sob a
orientação do Dr. Fernando Campos e supervisão da diretora técnica Drª. Maria
Octávia Vaz.
This dissertation is divided into two chapters: the first aims to present the research work carried out at the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI), the second is dedicated to the professional experience in Community Pharmacy. Chapter I is based on the research carried out at CICS-UBI, under the guidance of Professor Dr. Elisa Cairrão during the last year. According to the European Society of Endocrinology, endocrine disruptors (EDs) are chemical agents that mimic, block or interfere with natural hormone systems and their effects on health can last a lifetime and even have consequences for future generations. Diclofenac is known for its effects as an analgesic and anti-inflammatory, and is widely used for a variety of conditions, both acute and chronic, and consequently is one of the most commonly found drugs in the aquatic environment and has been found to have EDC effects in certain fish species. The aim of the present study was to evaluate the effect of Diclofenac (DCF) as an endocrine disruptor on human umbilical artery (AUH). By using an organ bath, the contractile response of the artery to the action of various contractile agents was studied. Subsequently, cumulative concentrations of diclofenac were applied and the differences in tension on the arteries were measured by isometric transducers. By analyzing the results, there was a greater relaxation of the arteries with increasing concentrations of Diclofenac, and this effect was most visible when subjected to the contractile agent histamine. However, more future studies are needed to understand the exact mechanism of this agent on vascular contractility in humans, particularly in the population with gestational hypertension. Chapter II summarizes the experience and learning obtained during the internship at Farmácia Moderna, in Tortosendo, between March 1st and July 15th 2021, under the guidance of Dr. Fernando Campos and supervision of the technical director Dr. Maria Octávia Vaz.
This dissertation is divided into two chapters: the first aims to present the research work carried out at the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI), the second is dedicated to the professional experience in Community Pharmacy. Chapter I is based on the research carried out at CICS-UBI, under the guidance of Professor Dr. Elisa Cairrão during the last year. According to the European Society of Endocrinology, endocrine disruptors (EDs) are chemical agents that mimic, block or interfere with natural hormone systems and their effects on health can last a lifetime and even have consequences for future generations. Diclofenac is known for its effects as an analgesic and anti-inflammatory, and is widely used for a variety of conditions, both acute and chronic, and consequently is one of the most commonly found drugs in the aquatic environment and has been found to have EDC effects in certain fish species. The aim of the present study was to evaluate the effect of Diclofenac (DCF) as an endocrine disruptor on human umbilical artery (AUH). By using an organ bath, the contractile response of the artery to the action of various contractile agents was studied. Subsequently, cumulative concentrations of diclofenac were applied and the differences in tension on the arteries were measured by isometric transducers. By analyzing the results, there was a greater relaxation of the arteries with increasing concentrations of Diclofenac, and this effect was most visible when subjected to the contractile agent histamine. However, more future studies are needed to understand the exact mechanism of this agent on vascular contractility in humans, particularly in the population with gestational hypertension. Chapter II summarizes the experience and learning obtained during the internship at Farmácia Moderna, in Tortosendo, between March 1st and July 15th 2021, under the guidance of Dr. Fernando Campos and supervision of the technical director Dr. Maria Octávia Vaz.
Description
Keywords
Artéria Umbilical Humana Diclofenac Disruptor Endócrino Farmácia Comunitária Tónus Vascular