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Abstract(s)
A presente dissertação é parte integrante da Unidade Curricular “Estágio” do Mestrado Integrado em Ciências Farmacêuticas. Está dividida em três capítulos, sendo que, o primeiro corresponde à vertente de Investigação, o segundo diz respeito à experiência de estágio em Farmácia Hospitalar e o terceiro à experiência de estágio em Farmácia Comunitária.
O Capítulo I diz respeito à revisão sistemática e metanálise sobre o efeito dos agonistas adrenérgicos ß2 no desempenho físico em indivíduos saudáveis. Os agonistas ß2 são um dos grupos de fármacos mais comumente usados para o tratamento da asma e da doença pulmonar obstrutiva crónica pelas suas propriedades broncodilatadoras. No entanto, diversos casos de doping levantaram a questão se além deste efeito poderão também ter efeito ergogénico, aumentado assim a performance atlética. O objetivo deste estudo foi rever sistematicamente a evidência científica disponível acerca do efeito dos ß2-agonistas no desempenho físico e realizar uma metánalise dos estudos incluídos. Foi efetuada uma pesquisa bibliográfica nas bases de dados dados PubMed, Scopus, Science Direct, ISI Web of Science e Cochrane Central Register of Controlled Trials entre o início das bases de dados e 31 de dezembro de 2018. Após a aplicação dos critérios de inclusão e exclusão previamente definidos, foram incluídos 53 estudos na revisão sistemática e 30 na metanálise. Os resultados observados sugerem que os agonistas ß2 administrados nas doses e vias de administração permitidas, não aumentam o desempenho físico de atletas saudáveis, uma vez que não ocorreu melhoria da performance, avaliada recorrendo a vários outcomes, quando comparados diretamente com placebo.
O Capítulo II descreve a minha experiência durante o estágio curricular em Farmácia Hospitalar, que decorreu entre 21 de janeiro e 8 de março de 2019, no Hospital Sousa Martins, sob orientação do Dr. Jorge Aperta. Durante este período, foi-me possível conhecer as áreas de intervenção de um Farmacêutico e desenvolver as capacidades técnico-científicas e de autonomia subjacentes à profissão em contexto hospitalar.
O Capítulo III faz referência à minha experiência durante o estágio curricular em Farmácia Comunitária, na Farmácia Holon Covilhã entre 11 de Março e 31 de Maio de 2019, sob orientação da Dr.ª Mafalda Silva. Este período de estágio permitiu-me contactar com as atividades diárias numa farmácia, aprender novos conceitos e desenvolver a minha capacidade de interação com os utentes.
This dissertation is an integral part of the “Internship” curricular unit of the Integrated Master’s Degree in Pharmaceutical Sciences. It is divided in three different chapters. The first chapter corresponds to the research section, the second concerns the internship in Hospital Pharmacy and the third one to the internship in Community Pharmacy. Chapter I refers to the systematic review and meta-analysis on the the effect of ß2 adrenergic agonists on physical performance in healthy individuals. ß2 agonists are one of the most commonly used drug groups in the treatment of asthma and chronic obstructive pulmonary disease, because of their bronchodilator properties. However, several cases of doping raised the question whether in addition to this effect they may also have ergogenic effects, thus increasing athletic performance. The aim of this study was to systematically review the available scientific evidence on the effect of ß2 agonists on physical performance and to perform a meta-analysis of the included studies. A bibliographic search was performed in PubMed, Scopus, Science Direct, ISI Web of Science and the Cochrane Central Register of Controlled Trials databases between the beginning of the databases and 31st December 2018. After application of the inclusion and exclusion criteria 53 studies were included in the systematic review and 30 were included in the meta-analysis. The observed results suggest that the ß2 Agonists, administered at the permitted doses and routes of administration, do not enhance the physical performance of healthy athletes, as evaluated by the different outomes revised when compared to placebo. Chapter II describes my experience in my internship in Hospital Pharmacy, which took place at “Hospital Sousa Martins” under the supervision of Dr. Jorge Aperta from 21st January to 8th March 2019. During this period, I was able to get to know the Pharmacist’s intervention areas, and develop my scientific, technical and autonomy capacities underlying the profession in a hospital context. Chapter III reports my experience during my internship in Community Pharmacy at “Farmácia Holon Covilhã” from 11th March to 31st May 2019, under the supervision of Dr.ª Mafalda Silva. This experience allowed me to have contact with the daily activities in a pharmacy, learn new concepts and develop my communication skills to interact with the patients.
This dissertation is an integral part of the “Internship” curricular unit of the Integrated Master’s Degree in Pharmaceutical Sciences. It is divided in three different chapters. The first chapter corresponds to the research section, the second concerns the internship in Hospital Pharmacy and the third one to the internship in Community Pharmacy. Chapter I refers to the systematic review and meta-analysis on the the effect of ß2 adrenergic agonists on physical performance in healthy individuals. ß2 agonists are one of the most commonly used drug groups in the treatment of asthma and chronic obstructive pulmonary disease, because of their bronchodilator properties. However, several cases of doping raised the question whether in addition to this effect they may also have ergogenic effects, thus increasing athletic performance. The aim of this study was to systematically review the available scientific evidence on the effect of ß2 agonists on physical performance and to perform a meta-analysis of the included studies. A bibliographic search was performed in PubMed, Scopus, Science Direct, ISI Web of Science and the Cochrane Central Register of Controlled Trials databases between the beginning of the databases and 31st December 2018. After application of the inclusion and exclusion criteria 53 studies were included in the systematic review and 30 were included in the meta-analysis. The observed results suggest that the ß2 Agonists, administered at the permitted doses and routes of administration, do not enhance the physical performance of healthy athletes, as evaluated by the different outomes revised when compared to placebo. Chapter II describes my experience in my internship in Hospital Pharmacy, which took place at “Hospital Sousa Martins” under the supervision of Dr. Jorge Aperta from 21st January to 8th March 2019. During this period, I was able to get to know the Pharmacist’s intervention areas, and develop my scientific, technical and autonomy capacities underlying the profession in a hospital context. Chapter III reports my experience during my internship in Community Pharmacy at “Farmácia Holon Covilhã” from 11th March to 31st May 2019, under the supervision of Dr.ª Mafalda Silva. This experience allowed me to have contact with the daily activities in a pharmacy, learn new concepts and develop my communication skills to interact with the patients.
Description
Keywords
Agonistas B2 Atletas Doping Farmácia Comunitária Farmácia Hospitalar Metanálise Revisão Sistemática