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Gold-core silica shell nanoparticles application in imaging and therapy: A review

2018-05-29Journal article Restricted access
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dc.contributor.authorMoreira, André
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorReis, Ana Catarina Almeida
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-08-23T09:02:24Z
dc.date.available2018-08-23T09:02:24Z
dc.date.issued2018-05-29
dc.description.abstractNanomaterials have assumed a prominent role in biomedical field during the past years. Particularly, the gold-core silica shell nanoparticles present unique physical and chemical properties that make nanodevices appealing for theragnostic applications. The gold core characteristic X-ray attenuation, surface enhanced raman scattering and tunable absorption in the near-infrared region supports the applicability of these systems in X-ray, photoacoustic and thermal imaging as well as in photothermal and photodynamic based therapies. Additionally, the inclusion of the silica shell stabilizes the gold core, protecting it from premature degradation and aggregation, and also provides additional cargo capacity for therapeutic molecules. Further, both silica and gold are described as biocompatible, inert and nontoxic materials. In this review, an overview of the gold core-silica shell nanoparticles applications in nanomedicine is provided, highlighting the different particle shapes and their application in bioimaging and therapy. Further, the basics of the gold core-silica shell nanoparticles synthesis procedures, general properties, and biosafety are also described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, A.F., Rodrigues, C.F., Reis. C.A., Costa, E.C., Correia, I.J. (2018) "Gold-Core Silica Shell Nanoparticles Application in Imaging and Therapy: a Review", Microporous and Mesoporous Materials, Vol. 270, pp. 168-179.pt_PT
dc.identifier.doi10.1016/j.micromeso.2018.05.022pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/5682
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S138718111830266Xpt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectNanomedicinept_PT
dc.subjectSilicapt_PT
dc.subjectImagingpt_PT
dc.subjectTherapypt_PT
dc.titleGold-core silica shell nanoparticles application in imaging and therapy: A reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.endPage179pt_PT
oaire.citation.startPage168pt_PT
oaire.citation.titleMicroporous and Mesoporous Materialspt_PT
oaire.citation.volume270pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameFélix Rodrigues
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameAna Carolina
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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