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Production and characterization of a novel asymmetric 3D printed construct aimed for skin tissue regeneration

2019-09-01Journal article Open access
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dc.contributor.authorMiguel, Sónia
dc.contributor.authorCabral, Cátia S. D.
dc.contributor.authorMoreira, André
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-08-26T09:28:08Z
dc.date.available2021-08-09T00:30:09Z
dc.date.issued2019-09-01
dc.description.abstractSkin is a complex organ that act as the first protective barrier against any external threat. After an injury occurs, its structure and functions must be re-established as soon as possible. Among different available skin substitutes (epidermal, dermal and dermo-epidermal), none of them is fully capable of reproducing/re-establishing all the features and functions of native skin. Herein, a three-dimensional skin asymmetric construct (3D_SAC) was produced using electrospinning and 3D bioprinting techniques. A poly(caprolactone) and silk sericin blend was electrospun to produce a top layer aimed to mimic the epidermis features, i.e. to provide a protective barrier against dehydration and hazard agents. In turn, the dermis like layer was formed by printing layer-by-layer a chitosan/sodium alginate hydrogel. The results obtained in the in vitro assays revealed that the 3D_SAC display a morphology, porosity, mechanical properties, wettability, antimicrobial activity and a cytotoxic profile that grants their application as a skin substitute during the healing process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSónia P. Miguel, Cátia S.D. Cabral, André F. Moreira, Ilídio J. Correia, Production and characterization of a novel asymmetric 3D printed construct aimed for skin tissue regeneration, Colloids and Surfaces B: Biointerfaces, Volume 181, 2019, Pages 994-1003, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2019.06.063.pt_PT
dc.identifier.doi10.1016/j.colsurfb.2019.06.063pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7179
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.subjectElectrospinningpt_PT
dc.subject3D bioprintingpt_PT
dc.subjectAsymmetric skin constructpt_PT
dc.subjectSkin regenerationpt_PT
dc.titleProduction and characterization of a novel asymmetric 3D printed construct aimed for skin tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.endPage1003pt_PT
oaire.citation.startPage994pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume181pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameCabral
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameCátia Solange Duarte
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos do artigo foram cedidos à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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