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Authors
Abstract(s)
Introdução: A Hipertensão Arterial (HTA) é uma doença com elevada prevalência a
nível mundial, sendo que para o seu tratamento é essencial a adesão do paciente às
alterações de estilo de vida e à terapêutica farmacológica. Neste contexto de cuidados
centrados no paciente, os Patient-Reported Outcome Measures (PROMs) têm particular
interesse, por obter informações sobre vários resultados da saúde da perspetiva do
paciente (PRO), o que permite melhorar os seus cuidados de saúde.
Objetivo: Identificar quais os PROMs genéricos ou específicos de HTA que estão a ser
aplicados para estudar doentes de HTA.
Métodos: Para esta revisão sistemática da literatura foram utilizadas as bases de dados
PubMed, B-on e Web of Science. Foram selecionados artigos escritos em inglês, espanhol
e português, com publicação entre 23 de março de 2019 e 23 de março de 2024. A data
da última pesquisa foi 23 de março de 2024. Foram incluídos artigos que aplicassem
PROMs genéricos ou específicos de HTA a adultos com HTA, e excluídos protocolos de
ensaios clínicos e estudos de desenvolvimento e/ou validação de PROMs. Para sintetizar
os dados extraídos dos estudos foi elaborada uma tabela no Excel.
Resultados: Foram obtidos 728 artigos da pesquisa nas bases de dados. Após remoção
de duplicados (n=503), foram submetidos a triagem do título e resumo 225 artigos, com
exclusão de 118 artigos nesta fase. Foram procurados 107 artigos para recuperação
integral, resultando em 85 artigos. Deste número foram excluídos 77 artigos, por não
cumprirem os critérios de elegibilidade, resultando num número final de 8 artigos. Estes
artigos foram publicados em países diferentes, com tipos de estudos diferentes e
tamanhos de amostra variáveis entre 140 a 1225. Foi identificado um total de 19 PROMs,
incluindo um PROMs específico da HTA, o MINICHAL, e os seguintes PROMs genéricos:
6 domínios do PROMIS; EQ-5D-3L e EQ-5D-5L, com o EQ-VAS aplicado isoladamente
também; SF-36 e SF-12; MMAS-8; TSQM 1.4; PHQ-8; GHQ-12; PSS; STAI; BDI-II;
HADS. Quanto aos domínios avaliados, houve um foco na saúde mental, seguido da
QVRS e da adesão à medicação.
Conclusão: Esta revisão sistemática da literatura identificou um número variado de
PROMs que avaliam diversos domínios, com destaque para o MINICHAL e os
questionários dos grupos PROMIS, EuroQOL e SF-36/SF-12. Tendo em conta o número de estudos incluídos, é necessária mais investigação nesta área para esclarecer quais os
instrumentos mais adequados, com desenvolvimento, validação e aplicação de mais
PROMs específicos de HTA.
Introduction: Arterial Hypertension (HTN) is a disease with a high prevalence worldwide, with patient adherence to lifestyle changes and pharmacologic therapy being essential to its treatment. In this context of patient-centered care, Patient-Reported Outcome Measures (PROMs) are of particular interest, since they provide information on various health outcomes from the patient’s perspective (PRO), with makes it possible to improve their healthcare. Objective: To identify which generic or HTA-specific PROMs are being applied to study HTA patients. Methods: The databases used for this systematic literature review were PubMed, B-on and Web of Science. Articles written in English, Spanish and Portuguese, and published between the 23rd of March, 2019 and the 23rd of March, 2024 were selected. The date of the last search was the 23rd of March, 2024. Articles that applied generic or HTA-specific PROMs on adults with HTA were included, and clinical trial protocols and PROMs development and/or validation studies were excluded. An Excel table was created to summarize the data extracted from the studies. Results: 728 articles were retrieved from the database search. After removing duplicates (n=503), the title and abstract of 225 articles were screened, with the exclusion of 118 articles in this phase. After searching for the full-text of 107 articles, 85 were retrieved. Of this number, 77 articles were excluded because they did not meet the eligibility criteria, resulting in a final number of 8 articles. These articles were published in different countries, with different types of studies and sample sizes ranging from 140 to 1225. A total of 19 PROMs were identified, including one PROMs specific to HTN, MINICHAL, and the following generic PROMs: 6 PROMIS domains; EQ-5D-3L and EQ5D-5L, with EQ-VAS also used alone; SF-36 and SF-12; MMAS-8; TSQM 1.4; PHQ-8; GHQ-12; PSS; STAI; BDI-II; HADS. As for the domains assessed, there was a focus on mental health, followed by HRQoL and medication adherence. Conclusion: This systematic review of the literature identified a diverse number of PROMs that assess various domains, with MINICHAL and the questionnaires from the PROMIS, EuroQOL and SF-36/SF-12 groups standing out. Given the number of studies included, more research is needed in this area to clarify which instruments are most suitable, with development, validation and application of more HTA-specific PROMs.
Introduction: Arterial Hypertension (HTN) is a disease with a high prevalence worldwide, with patient adherence to lifestyle changes and pharmacologic therapy being essential to its treatment. In this context of patient-centered care, Patient-Reported Outcome Measures (PROMs) are of particular interest, since they provide information on various health outcomes from the patient’s perspective (PRO), with makes it possible to improve their healthcare. Objective: To identify which generic or HTA-specific PROMs are being applied to study HTA patients. Methods: The databases used for this systematic literature review were PubMed, B-on and Web of Science. Articles written in English, Spanish and Portuguese, and published between the 23rd of March, 2019 and the 23rd of March, 2024 were selected. The date of the last search was the 23rd of March, 2024. Articles that applied generic or HTA-specific PROMs on adults with HTA were included, and clinical trial protocols and PROMs development and/or validation studies were excluded. An Excel table was created to summarize the data extracted from the studies. Results: 728 articles were retrieved from the database search. After removing duplicates (n=503), the title and abstract of 225 articles were screened, with the exclusion of 118 articles in this phase. After searching for the full-text of 107 articles, 85 were retrieved. Of this number, 77 articles were excluded because they did not meet the eligibility criteria, resulting in a final number of 8 articles. These articles were published in different countries, with different types of studies and sample sizes ranging from 140 to 1225. A total of 19 PROMs were identified, including one PROMs specific to HTN, MINICHAL, and the following generic PROMs: 6 PROMIS domains; EQ-5D-3L and EQ5D-5L, with EQ-VAS also used alone; SF-36 and SF-12; MMAS-8; TSQM 1.4; PHQ-8; GHQ-12; PSS; STAI; BDI-II; HADS. As for the domains assessed, there was a focus on mental health, followed by HRQoL and medication adherence. Conclusion: This systematic review of the literature identified a diverse number of PROMs that assess various domains, with MINICHAL and the questionnaires from the PROMIS, EuroQOL and SF-36/SF-12 groups standing out. Given the number of studies included, more research is needed in this area to clarify which instruments are most suitable, with development, validation and application of more HTA-specific PROMs.
Description
Keywords
Hipertensão Arterial Patient-Reported Outcome Measures Patient-Reported Outcomes Questionários