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Abstract(s)
O presente relatório para obtenção do Grau de Mestre em Ciências Farmacêuticas encontrase dividido em dois capítulos.
O Capítulo I é referente à componente de investigação e consiste numa revisão bibliográfica
denominada “Estudo dos efeitos tóxicos de anti-inflamatórios não esteroides em animais
de companhia”. Este tema torna-se relevante uma vez que o panorama geral das famílias
portuguesas inclui cada vez mais animais de companhia, como cães e gatos. Deste modo, os
cuidados com a saúde animal seguem uma tendência crescente, por vezes, implicando a
administração de fármacos (entre os quais os anti-inflamatórios não esteroides) que, apesar
do seu potencial terapêutico, podem desencadear reações adversas. Neste sentido,
reuniram-se informações da última década acerca da toxicidade, doses terapêuticas e
tóxicas, e ainda medidas de tratamento a aplicar em caso de sobredosagem com os antiinflamatórios não esteroides aprovados em Portugal, nesta população alvo. Verificou-se,
portanto, que têm vindo a aumentar as notificações aos Sistemas de Farmacovigilância,
quer a nível nacional, quer a nível europeu. Também se observou que, desde 2010, têm sido
realizados ensaios clínicos tanto de curta, como de longa duração, com a maioria dos
fármacos estudados e vão sendo publicados case reports relativos a situações de
sobredosagem acidental, tanto em ambiente doméstico, como em ambiente de clínica
veterinária, e mesmo devido a erros de dispensa em farmácia comunitária. Apesar da
indicação geral referida nos Resumos das Características dos Medicamentos Veterinários
em caso de sobredosagem ser para aplicar tratamento de suporte geral, foram relatados
quadros em que se utilizaram outras medidas terapêuticas, apresentando-se como
vantajosas. Assim, concluiu-se que, embora a informação neste âmbito continue a surgir e
os fármacos sejam desenvolvidos cada vez mais de forma a evitar a toxicidade, ainda há um
caminho a percorrer para que a segurança destes seja otimizada e se reduzam as suas
reações adversas, principalmente em terapêuticas de longa duração.
O Capítulo II descreve a minha experiência profissionalizante no decorrer do estágio
curricular em Farmácia Comunitária na Farmácia Sousa Trincão (Abrantes), entre março e
julho de 2021, sob a orientação da Dr.ª Maria do Rosário Sousa e Trincão. Este período de
aprendizagem apresentou uma enorme importância na minha formação enquanto
farmacêutica, sendo especialmente desafiante devido ao atual contexto pandémico.
This project, for obtaining the Master's Degree in Pharmaceutical Sciences, is divided into two chapters. Chapter I refers to my research component and consists of a literature review named “Study of the toxic effects of non-steroidal anti-inflammatory drugs in companion animals”. This theme becomes relevant nowadays since the general panorama of Portuguese families already includes animals, such as dogs and cats. Thus, animal health care follows its growing trend, which sometimes involves the administration of drugs (including non-steroidal antiinflammatory drugs); however, despite their therapeutic potential, these substances can present adverse reactions. In this regard, information was gathered from the last decade about toxicity, therapeutic and toxic doses, and also treatment measures to be applied in the event of an overdose with the non-steroidal anti-inflammatory drugs approved in Portugal, for this target population. It was therefore verified that notifications to Pharmacovigilance Systems have been increasing, both nationally and at European level. It was also observed that, since 2010, clinical trials have been carried out, both short and long term, with most of the drugs studied, and case reports have been published on situations of accidental overdose, whether at home or in veterinary clinics, and even due to dispensing errors in community pharmacy. Despite the indications mentioned in the package leaflet in the event of an overdose to apply general supportive treatment, cases with other therapeutic measures were reported, presenting advantages. Thus, it was concluded that, although information in this area continues to emerge and drugs are increasingly developed in order to avoid toxicity, there is still a way to go so that their safety is optimized and their adverse reactions reduced, mainly in long-term therapies. Chapter II describes my professional experience during the curricular internship in Community Pharmacy at Farmácia Sousa Trincão (Abrantes), between March and July 2021, under the guidance of Dr. Maria do Rosário Sousa e Trincão. This learning period was extremely important for my training as a pharmacist, being especially challenging due to the current pandemic context.
This project, for obtaining the Master's Degree in Pharmaceutical Sciences, is divided into two chapters. Chapter I refers to my research component and consists of a literature review named “Study of the toxic effects of non-steroidal anti-inflammatory drugs in companion animals”. This theme becomes relevant nowadays since the general panorama of Portuguese families already includes animals, such as dogs and cats. Thus, animal health care follows its growing trend, which sometimes involves the administration of drugs (including non-steroidal antiinflammatory drugs); however, despite their therapeutic potential, these substances can present adverse reactions. In this regard, information was gathered from the last decade about toxicity, therapeutic and toxic doses, and also treatment measures to be applied in the event of an overdose with the non-steroidal anti-inflammatory drugs approved in Portugal, for this target population. It was therefore verified that notifications to Pharmacovigilance Systems have been increasing, both nationally and at European level. It was also observed that, since 2010, clinical trials have been carried out, both short and long term, with most of the drugs studied, and case reports have been published on situations of accidental overdose, whether at home or in veterinary clinics, and even due to dispensing errors in community pharmacy. Despite the indications mentioned in the package leaflet in the event of an overdose to apply general supportive treatment, cases with other therapeutic measures were reported, presenting advantages. Thus, it was concluded that, although information in this area continues to emerge and drugs are increasingly developed in order to avoid toxicity, there is still a way to go so that their safety is optimized and their adverse reactions reduced, mainly in long-term therapies. Chapter II describes my professional experience during the curricular internship in Community Pharmacy at Farmácia Sousa Trincão (Abrantes), between March and July 2021, under the guidance of Dr. Maria do Rosário Sousa e Trincão. This learning period was extremely important for my training as a pharmacist, being especially challenging due to the current pandemic context.
Description
Keywords
Animais de Companhia Anti-Inflamatórios Não Esteroides Farmácia Comunitária Toxicidade