| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 638.52 KB | Adobe PDF |
Authors
Abstract(s)
Introdução: A Mola Hidatiforme é uma entidade patológica, relativamente infrequente, pertencente ao leque de doenças designadas por Doença Trofoblástica Gestacional, que resultam de uma anormal proliferação e diferenciação do tecido trofoblástico. A Mola Hidatiforme é uma condição não maligna, mas com potencial de progressão oncológica, podendo ser ameaçadora da vida. Pelas suas características epidemiológicas, citogenéticas, patológicas, história natural e apresentação clínica, é dividida em Mola Hidatiforme Completa e Mola Hidatiforme Parcial. A existência de uma Mola Hidatiforme prévia e os extremos de idade materna (<20 anos e >35 anos), são os fatores de risco mais aceites para a ocorrência da doença. Outros fatores de risco estão descritos, porém não são consensuais.
Objetivo: Analisar e discutir os dados relativos à incidência da Mola Hidatiforme, complicações e recidiva, como também verificar a existência posterior de aborto espontâneo ou gestação de termo sem intercorrências, nos casos ocorridos no Centro Hospitalar Cova da Beira, ao longo de 16 anos.
Materiais e Métodos: Estudo observacional retrospetivo através de consulta de dados processuais de mulheres com o diagnóstico clínico de Mola Hidatiforme no Centro Hospitalar Cova da Beira no período entre janeiro de 2000 e dezembro de 2016 (n=10), tendo sido excluídas as mulheres sem confirmação histológica, perfazendo uma amostra final de 6 mulheres. A análise descritiva dos dados foi feita com base no software IBM SPSS Statistics e foram utilizados métodos de análise descritiva, como resumo de casos, análise de frequências e análise descritivas de variáveis.
Resultados: No decorrer de 16 anos, foram diagnosticadas 6 mulheres com Mola Hidatiforme, confirmadas por relatório anatomopatológico, representando uma incidência de cerca de 0.55 por 1000 partos. A idade das mulheres diagnosticadas variou entre os 23 e 42 anos, sendo que apenas 1 (16,7%) dessas mulheres se encontrava no extremo de idade materna superior a 40 anos. Em 2 das pacientes (33,3%) o valor de ßhCG manteve-se elevado após evacuação do conteúdo uterino, tendo sido diagnosticadas com Mola Invasiva. Após o diagnóstico e tratamento da Mola Hidatiforme, 2 das mulheres (33,3%) voltaram a engravidar, alcançando ambas gestações de termo. As restantes 4 (66,7%) não tiveram mais gestações no período de tempo analisado. Não se verificaram recorrências de mola hidatiforme em nenhuma das pacientes.
Discussão: Apesar do risco aumentado de recidiva, mulheres previamente diagnosticadas com mola hidatiforme podem esperar voltar a engravidar e alcançar uma gestação de termo, sendo, porém, recomendado um acompanhamento mais cuidadoso em todas as gestações futuras.
Introduction: The Hydatidiform Mole is a relatively uncommon pathologic entity that belongs to the range of diseases called Gestational Trophoblastic Disease, that arises from an abnormal proliferation and differentiation of trophoblastic tissue. The hydatidiform mole is a non-malignant condition, but with potential for oncological progression, and can be life threatening. Due to its epidemiological, cytogenetic, pathological, natural history and clinical presentation characteristics, it is divided into Complete Hydatidiform Mole and Partial Hydatidiform Mole. The existence of a previous hydatidiform mole and the extremes of maternal age (<20 years and >35 years) are the most established risk factors for the occurrence of the disease. Other risk factors are described, but they are not consensual. Objective: To analyse and discuss the data on the incidence of hydatidiform mole, complications and relapse, as well as to verify the existence of spontaneous abortion or term gestation without complications, in the cases occurred in the Cova da Beira Hospital Centre, for 16 years. Materials and Methods: Retrospective observational study, through consultation of procedural data of all women with a clinical diagnosis of Hydatidiform Mole at the Cova da Beira Hospital Centre between January 2000 and December 2016 (n = 10), with women without histological confirmation being excluded, making up a final sample of 6 women. The descriptive analysis of the data was made based on the IBM SPSS Statistics software and descriptive analysis methods were used, such as case summary, frequency analysis and descriptive analysis of variables. Results: In 16 years, 6 women were diagnosed with Hydatidiform Mole, confirmed by anatomopathological report, representing an incidence of about 0.55 per 1000 births. The age of the diagnosed women ranged from 23 to 42 years of age, and only 1 (16.7%) of these women were in the extreme maternal age of over 40 years. In 2 of the patients (33.3%) the value of ßhCG remained elevated after evacuation of the uterine contents, having been diagnosed with Invasive Mole. After diagnosis and treatment of the Hydatidiform Mole, 2 of the women (33.3%) re-conceived, reaching both term pregnancies. The remaining 4 (66.7%) did not have more pregnancies in the analysed period of time. There were no recurrences of hydatidiform mole in any of the patients. Discussion: Despite the increased risk of recurrence, women previously diagnosed with hydatidiform mole may expect to conceive again and achieve full term gestation, but more careful follow-up is recommended in all future pregnancies.
Introduction: The Hydatidiform Mole is a relatively uncommon pathologic entity that belongs to the range of diseases called Gestational Trophoblastic Disease, that arises from an abnormal proliferation and differentiation of trophoblastic tissue. The hydatidiform mole is a non-malignant condition, but with potential for oncological progression, and can be life threatening. Due to its epidemiological, cytogenetic, pathological, natural history and clinical presentation characteristics, it is divided into Complete Hydatidiform Mole and Partial Hydatidiform Mole. The existence of a previous hydatidiform mole and the extremes of maternal age (<20 years and >35 years) are the most established risk factors for the occurrence of the disease. Other risk factors are described, but they are not consensual. Objective: To analyse and discuss the data on the incidence of hydatidiform mole, complications and relapse, as well as to verify the existence of spontaneous abortion or term gestation without complications, in the cases occurred in the Cova da Beira Hospital Centre, for 16 years. Materials and Methods: Retrospective observational study, through consultation of procedural data of all women with a clinical diagnosis of Hydatidiform Mole at the Cova da Beira Hospital Centre between January 2000 and December 2016 (n = 10), with women without histological confirmation being excluded, making up a final sample of 6 women. The descriptive analysis of the data was made based on the IBM SPSS Statistics software and descriptive analysis methods were used, such as case summary, frequency analysis and descriptive analysis of variables. Results: In 16 years, 6 women were diagnosed with Hydatidiform Mole, confirmed by anatomopathological report, representing an incidence of about 0.55 per 1000 births. The age of the diagnosed women ranged from 23 to 42 years of age, and only 1 (16.7%) of these women were in the extreme maternal age of over 40 years. In 2 of the patients (33.3%) the value of ßhCG remained elevated after evacuation of the uterine contents, having been diagnosed with Invasive Mole. After diagnosis and treatment of the Hydatidiform Mole, 2 of the women (33.3%) re-conceived, reaching both term pregnancies. The remaining 4 (66.7%) did not have more pregnancies in the analysed period of time. There were no recurrences of hydatidiform mole in any of the patients. Discussion: Despite the increased risk of recurrence, women previously diagnosed with hydatidiform mole may expect to conceive again and achieve full term gestation, but more careful follow-up is recommended in all future pregnancies.
Description
Keywords
Complicações da Gravidez Doença Trofoblástica Gestacional (Dtg) Gravidez Molar Mola Hidatiforme (Mh) Mola Invasiva