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Authors
Abstract(s)
O presente relatório constitui o desafio final da jornada para a obtenção do grau de
Mestre em Ciências Farmacêuticas. Encontra-se dividido em três capítulos principais:
O primeiro descreve o projeto de investigação desenvolvido no Centro de Investigação
em Ciências da Saúde, da Universidade da Beira Interior (CICS-UBI), orientado pelas
Professoras Doutoras Ana Paula Coelho Duarte e Maria Eugenia Gallardo Alba. Este
teve como objetivo avaliar os componentes bioativos de suplementos alimentares,
disponíveis comercialmente, à base de plantas medicinais particularmente, Passiflora
incarnata L. (Passiflora), Silybum marianum (Cardo mariano) e Arctostaphylos uvaursi (Uva ursina).
Procurámos identificar e quantificar os ingredientes ativos integrantes da
suplementação à base de plantas, a fim de averiguar e comparar o cumprimento em
termos de orientações de dosagem e aplicações, recomendações e regulamentações
disponíveis. Na caracterização dos padrões comerciais, referentes aos compostos em
análise, bem como dos suplementos alimentares, recorremos à técnica de
cromatografia líquida de alta eficiência, com detetor de díodos (HPLC-DAD). Com a
técnica desenvolvida no presente documento, foi possível identificar e quantificar os
compostos ativos presentes nos produtos comercializados em Portugal.
O segundo e terceiro capítulos descrevem o conhecimento e experiência adquiridos no
decorrer de dois estágios curriculares designadamente, estágio em Farmácia
Hospitalar, realizado no Hospital Universitário Cova da Beira, na Covilhã, sob a
orientação da Professora Doutora Maria Olímpia Cardoso Ferreira da Fonseca; e
estágio em Farmácia Comunitária, concretizado na Farmácia Sant’Ana, também na
Covilhã, sob orientação da Doutora Paula Goulão Bártolo.
This report constitutes the final challenge of the journey towards the degree of Master of Pharmaceutical Sciences. The report is divided into three main chapters: The first chapter describes the research project developed at the Health Sciences Research Centre, University of Beira Interior (CICS-UBI), supervised by Professors Ana Paula Coelho Duarte and Maria Eugenia Gallardo Alba. This aimed to evaluate the bioactive components of food supplements, commercially available, based on medicinal plants, particularly Passiflora incarnata L. (Passiflora), Silybum marianum (Milk Thistle) and Arctostaphylos uva-ursi (Bearberry). We have attempted to identify and quantify the active ingredients comprising herbal supplementation in order to ascertain and compare compliance in terms of dosage and application guidelines, recommendations and available regulations. In the characterization of the commercial standards, referring to the compounds under analysis, as well as the food supplements, we used the technique of high performance liquid chromatography coupled to diode array detector (HPLC-DAD). With the technique developed in this document it was possible to identify and quantify the active compounds present in the products marketed in Portugal. The second and third chapters describe the knowledge and experience acquired during two curricular internships, specifically, the internship served in Hospital Pharmacy, carried out in Hospital Universitário Cova da Beira, in Covilhã, under the supervision of Professor Maria Olímpia Cardoso Ferreira da Fonseca; and the internship in Community Pharmacy, carried out in Farmácia Sant'Ana, also in Covilhã, under the supervision of Dr. Paula Goulão Bártolo.
This report constitutes the final challenge of the journey towards the degree of Master of Pharmaceutical Sciences. The report is divided into three main chapters: The first chapter describes the research project developed at the Health Sciences Research Centre, University of Beira Interior (CICS-UBI), supervised by Professors Ana Paula Coelho Duarte and Maria Eugenia Gallardo Alba. This aimed to evaluate the bioactive components of food supplements, commercially available, based on medicinal plants, particularly Passiflora incarnata L. (Passiflora), Silybum marianum (Milk Thistle) and Arctostaphylos uva-ursi (Bearberry). We have attempted to identify and quantify the active ingredients comprising herbal supplementation in order to ascertain and compare compliance in terms of dosage and application guidelines, recommendations and available regulations. In the characterization of the commercial standards, referring to the compounds under analysis, as well as the food supplements, we used the technique of high performance liquid chromatography coupled to diode array detector (HPLC-DAD). With the technique developed in this document it was possible to identify and quantify the active compounds present in the products marketed in Portugal. The second and third chapters describe the knowledge and experience acquired during two curricular internships, specifically, the internship served in Hospital Pharmacy, carried out in Hospital Universitário Cova da Beira, in Covilhã, under the supervision of Professor Maria Olímpia Cardoso Ferreira da Fonseca; and the internship in Community Pharmacy, carried out in Farmácia Sant'Ana, also in Covilhã, under the supervision of Dr. Paula Goulão Bártolo.
Description
Keywords
Componente Bioativo Farmácia Comunitária Farmácia Hospitalar Fitoterapia Hplc-Dad Qualidade Suplementos Alimentares