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Advisor(s)
Abstract(s)
A profissão farmacêutica é versátil, exigindo aptidões técnicas e científicas para
contribuir nas diferentes áreas da saúde e da ciência. A formação académica
multidisciplinar prepara os futuros profissionais para o exercício da sua atividade tanto
em farmácia hospitalar, como em farmácia comunitária e colaborar para o
desenvolvimento de projetos na vertente de investigação científica.
O farmacêutico hospitalar desempenha um papel crucial numa equipa de saúde
multidisciplinar em ambiente hospitalar. Nesta área, o farmacêutico é responsável pela
aquisição, gestão, preparação e distribuição de medicamentos, além de fornecer
informações clínicas, científicas e financeiras importantes para o sistema de saúde,
incluindo a avaliação da inovação terapêutica e a monitorização de ensaios clínicos.
Por outro lado, o farmacêutico comunitário desempenha um papel fundamental na
gestão da terapêutica, administração de medicamentos, identificação de pessoas em
risco, deteção precoce de doenças e promoção de estilos de vida saudáveis, devido à sua
posição privilegiada na comunidade.
O presente trabalho encontra-se dividido em três capítulos distintos, sendo o Capítulo I
referente à componente de investigação científica, o Capítulo II concernente à
experiência profissionalizante em Farmácia Hospitalar e o Capítulo III alusivo à
experiência profissionalizante em Farmácia Comunitária
O primeiro capítulo é composto por um trabalho de revisão sistemática desenvolvido na
área de neuroproteção pós-AVC, com base em ensaios clínicos realizados nos últimos
sete anos e em estudos pré-clínicos publicados nos últimos cinco anos, o qual permitiu
reunir atuais evidências relativamente à eficácia neuroprotetora de três grupos
farmacológicos: estatinas, progestinas e antiepilépticos, tendo em consideração várias
vias de administração. Através deste estudo de revisão sistemática foi possível
determinar, dentro de cada grupo, os fármacos que têm revelado um maior impacto em
termos de capacidade de neuroprotecção e propor potenciais abordagens para futuros
estudos, com base nos resultados que se têm mostrado promissores quanto à promoção
da remodelação neurítica e recuperação funcional pós-AVC, nomeadamente no que se
refere às potenciais vias de administração, novas abordagens terapêuticas, de um modo
particular as abordagens terapêuticas baseadas no uso de células estaminais em
combinação com alguns fármacos destes grupos, e a inclusão de iniciativas inovadoras, como a aplicação de um design adaptativo aos ensaios clínicos, de modo a superar a falta
de sucesso verificada em ensaios clínicos recentes.
No segundo capítulo é feita uma abordagem ao estágio em Farmácia Hospitalar, o qual
foi realizado nos Serviços Farmacêuticos do Centro Hospitalar Universitário Cova da
Beira, no período compreendido entre 6 de fevereiro e 31 de março de 2023, perfazendo
um total de 352 horas, sob a orientação da diretora dos SFH, Professora Doutora Maria
Olímpia Fonseca. Neste capítulo encontram-se descritas as competências adquiridas
durante o estágio, assim como cada uma das principais áreas dos serviços farmacêuticos
deste centro hospitalar: Setor de Aquisição e Logística, Setor de Dose Unitária, Setor de
Ambulatório e Setor de Farmacotecnia.
O terceiro capítulo descreve a experiência do estágio em Farmácia Comunitária,
realizado na Farmácia São João, na Covilhã, no período de 3 de abril a 20 de junho de
2021, com um total de 448 horas, sob a orientação da Dra. Dina Esteves. Neste capítulo
é feita a descrição da gestão e funcionamento da farmácia, sendo especificadas as tarefas
e atividades desempenhadas durante o estágio.
The pharmaceutical profession is versatile, requiring technical and scientific skills to contribute to different areas of health and science. Multidisciplinary academic training prepares future professionals to carry out their activities both in hospital pharmacy and community pharmacy and to collaborate in the development of projects in the field of scientific research. The hospital pharmacist performs a crucial role in a multidisciplinary healthcare team in a hospital environment. In this field, the pharmacist is responsible for the acquisition, management, preparation, and distribution of medicines, in addition to providing important clinical, scientific, and financial information for the health system, including the evaluation of therapeutic innovation and the monitoring of clinical trials. On the other hand, the community pharmacist plays a fundamental role in managing therapy, administering medications, identifying people at risk, early detection of diseases, and promoting healthy lifestyles due to their privileged position in the community. This work is divided into three distinct chapters, with Chapter I referring to the scientific research component, Chapter II concerning professional experience in hospital pharmacy, and Chapter III related to professional experience in the community pharmacy. The first chapter consists of a systematic review developed in the area of post-stroke neuroprotection based on clinical trials carried out in the last seven years and pre-clinical studies published in the last five years. This study provided current evidence regarding the neuroprotective efficacy of three pharmacological groups: statins, progestins, and antiepileptics, taking into account various routes of administration. Through this systematic review, it was possible to determine, within each group, the pharmacological substances that have shown a higher impact in terms of neuroprotective capacity and to propose potential approaches for future studies based on promising results in terms of neuroprotection promoting, neuritic remodelling and post-stroke functional recovery, particularly with regard to potential routes of administration, new therapeutic approaches, in specific therapeutic approaches based on the use of stem cells in combination with some medications from these groups, and the inclusion of innovative initiatives, such as applying adaptive design to clinical trials, in order to overcome the lack of success seen in recent clinical trials. In the second chapter, an approach was made to the internship in Hospital Pharmacy, which was carried out in the Pharmaceutical Services of the University Hospital Centre Cova da Beira, in the period between February 6th and March 31st, 2023, totalling 352 hours, under the guidance of the Pharmaceutical Care Division director, Professor Maria Olímpia Fonseca. This chapter describes the skills acquired during the internship as well as each of the main areas of pharmaceutical services at this hospital centre: the Acquisition and Logistics Sector, Unit Dose Sector, Outpatient Department, and Pharmacotechnics Sector. The third chapter describes the experience of the Community Pharmacy internship, carried out at Farmácia São João, in Covilhã, from April 3rd to June 20th, 2021, with a total of 448 hours, under the supervision of Dr. Dina Esteves. This chapter describes the management and operation of the pharmacy, specifying the tasks and activities performed during the internship.
The pharmaceutical profession is versatile, requiring technical and scientific skills to contribute to different areas of health and science. Multidisciplinary academic training prepares future professionals to carry out their activities both in hospital pharmacy and community pharmacy and to collaborate in the development of projects in the field of scientific research. The hospital pharmacist performs a crucial role in a multidisciplinary healthcare team in a hospital environment. In this field, the pharmacist is responsible for the acquisition, management, preparation, and distribution of medicines, in addition to providing important clinical, scientific, and financial information for the health system, including the evaluation of therapeutic innovation and the monitoring of clinical trials. On the other hand, the community pharmacist plays a fundamental role in managing therapy, administering medications, identifying people at risk, early detection of diseases, and promoting healthy lifestyles due to their privileged position in the community. This work is divided into three distinct chapters, with Chapter I referring to the scientific research component, Chapter II concerning professional experience in hospital pharmacy, and Chapter III related to professional experience in the community pharmacy. The first chapter consists of a systematic review developed in the area of post-stroke neuroprotection based on clinical trials carried out in the last seven years and pre-clinical studies published in the last five years. This study provided current evidence regarding the neuroprotective efficacy of three pharmacological groups: statins, progestins, and antiepileptics, taking into account various routes of administration. Through this systematic review, it was possible to determine, within each group, the pharmacological substances that have shown a higher impact in terms of neuroprotective capacity and to propose potential approaches for future studies based on promising results in terms of neuroprotection promoting, neuritic remodelling and post-stroke functional recovery, particularly with regard to potential routes of administration, new therapeutic approaches, in specific therapeutic approaches based on the use of stem cells in combination with some medications from these groups, and the inclusion of innovative initiatives, such as applying adaptive design to clinical trials, in order to overcome the lack of success seen in recent clinical trials. In the second chapter, an approach was made to the internship in Hospital Pharmacy, which was carried out in the Pharmaceutical Services of the University Hospital Centre Cova da Beira, in the period between February 6th and March 31st, 2023, totalling 352 hours, under the guidance of the Pharmaceutical Care Division director, Professor Maria Olímpia Fonseca. This chapter describes the skills acquired during the internship as well as each of the main areas of pharmaceutical services at this hospital centre: the Acquisition and Logistics Sector, Unit Dose Sector, Outpatient Department, and Pharmacotechnics Sector. The third chapter describes the experience of the Community Pharmacy internship, carried out at Farmácia São João, in Covilhã, from April 3rd to June 20th, 2021, with a total of 448 hours, under the supervision of Dr. Dina Esteves. This chapter describes the management and operation of the pharmacy, specifying the tasks and activities performed during the internship.
Description
Keywords
Agentes Neuroprotetores Antiepilépticos Avc Estatinas Farmácia Comunitária Farmácia Hospitalar Progestinas Vias de
Administração