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Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy

2022-09-13Journal article Open access
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dc.contributor.authorFigueiredo, André Q.
dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorFernandes, Natanael
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorCorreia, I.J.
dc.contributor.authorMoreira, André
dc.date.accessioned2023-01-03T15:39:11Z
dc.date.available2023-01-03T15:39:11Z
dc.date.issued2022-09-13
dc.description.abstractMetallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics. Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and radical oxygen species generation capacity displayed by metallic nanoparticles make them highly promising theragnostic solutions. Nevertheless, metallic-based nanoparticles are often associated with some toxicological issues, lack of colloidal stability, and establishment of off-target interactions. Therefore, researchers have been exploiting the combination of metallic nanoparticles with other materials, inorganic (e.g., silica) and/or organic (e.g., polymers). In terms of biological performance, metalpolymer conjugation can be advantageous for improving biocompatibility, colloidal stability, and tumor specificity. In this review, the application of metallic-polymer nanoconjugates/nanohybrids as a multifunctional all-in-one solution for cancer therapy will be summarized, focusing on the physicochemical properties that make metallic nanomaterials capable of acting as imaging and/or therapeutic agents. Then, an overview of the main advantages of metal-polymer conjugation as well as the most common structural arrangements will be provided. Moreover, the application of metallic-polymer nanoconjugates/nanohybrids made of gold, iron, copper, and other metals in cancer therapy will be discussed, in addition to an outlook of the current solution in clinical trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFigueiredo, A.Q.; Rodrigues, C.F.; Fernandes, N.; de Melo-Diogo, D.; Correia, I.J.; Moreira, A.F. Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy. Nanomaterials 2022, 12, 3166. https://doi.org/10.3390/ nano12183166pt_PT
dc.identifier.doi10.3390/nano12183166pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12577
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMetallic nanoparticlespt_PT
dc.subjectMetal-polymer nanoconjugatespt_PT
dc.subjectCancerpt_PT
dc.subjectPhotothermal effectpt_PT
dc.titleMetal-Polymer Nanoconjugates Application in Cancer Imaging and Therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue18pt_PT
oaire.citation.startPage3166pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamCEEC IND4ed
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFigueiredo
person.familyNameFélix Rodrigues
person.familyNameFernandes
person.familyNameMiguel de Melo Diogo
person.familyNameJoaquim Sobreira Correia
person.familyNameMoreira
person.givenNameAndré Filipe Quelhas
person.givenNameAna Carolina
person.givenNameNatanael
person.givenNameDuarte
person.givenNameIlídio
person.givenNameAndré Ferreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier1161643
person.identifier.ciencia-id141C-A5C2-BBEC
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2315-CC5A-3DBB
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-7737-9288
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0604-2506
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56401521300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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