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Orientador(es)
Resumo(s)
Metallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics.
Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and
radical oxygen species generation capacity displayed by metallic nanoparticles make them highly
promising theragnostic solutions. Nevertheless, metallic-based nanoparticles are often associated with
some toxicological issues, lack of colloidal stability, and establishment of off-target interactions. Therefore, researchers have been exploiting the combination of metallic nanoparticles with other materials,
inorganic (e.g., silica) and/or organic (e.g., polymers). In terms of biological performance, metalpolymer conjugation can be advantageous for improving biocompatibility, colloidal stability, and
tumor specificity. In this review, the application of metallic-polymer nanoconjugates/nanohybrids
as a multifunctional all-in-one solution for cancer therapy will be summarized, focusing on the
physicochemical properties that make metallic nanomaterials capable of acting as imaging and/or
therapeutic agents. Then, an overview of the main advantages of metal-polymer conjugation as
well as the most common structural arrangements will be provided. Moreover, the application of
metallic-polymer nanoconjugates/nanohybrids made of gold, iron, copper, and other metals in cancer
therapy will be discussed, in addition to an outlook of the current solution in clinical trials.
Descrição
Palavras-chave
Metallic nanoparticles Metal-polymer nanoconjugates Cancer Photothermal effect
Contexto Educativo
Citação
Figueiredo, A.Q.; Rodrigues, C.F.; Fernandes, N.; de Melo-Diogo, D.; Correia, I.J.; Moreira, A.F. Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy. Nanomaterials 2022, 12, 3166. https://doi.org/10.3390/ nano12183166
Editora
MDPI