| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.54 MB | Adobe PDF |
Abstract(s)
A presente dissertação descreve a minha experiência profissionalizante para a obtenção do
grau de Mestre em Ciências Farmacêuticas em duas vertentes, sendo elas, Farmácia
Comunitária e Investigação.
O Capítulo I descreve todo o trabalho de investigação desenvolvido. A Atresia Biliar é a
causa mais frequente de colestase neonatal e o motivo principal para a realização de
transplante hepático em crianças. A etiologia da Atresia Biliar permanece pouco esclarecida,
podendo em alguns casos resultar de um conjunto de fatores em associação com a
constituição genética e epigenética dos doentes. Tendo em conta o grande número de
referências na literatura relativamente a fatores ambientais e epigenéticos associados à
patofisiologia, poderá realmente existir uma relação causa-efeito? Estre trabalho teve por
objetivo, através da revisão sistemática da literatura, integrar a informação disponível nos
estudos científicos sobre o papel dos fatores epigenéticos e ambientais na patofisiologia da
Atresia Biliar e eventualmente, fatores epigenéticos ambientais mais preponderantes e
descritos para a patofisiologia e aparecimento da patologia em recém-nascidos. Apesar de
já existir alguma investigação em epigenética, a maioria é realizada em modelos animais,
sendo necessários realizar mais estudos para identificar os fatores e as suas vias de atuação
na patologia. No entanto, apesar da patofisiologia da Atresia Biliar ser complexa e repleta
de nuances, os fatores epigenéticos (microRNAs e metilação do DNA) e ambientais (toxinas
e hipoxia) assumem um papel importante, não apenas da patogénese, mas também no
diagnóstico precoce da doença.
O Capítulo II é preenchido pelo Relatório de Estágio em Farmácia Comunitária, onde é
descrita a experiência de estágio na Farmácia São João, na Covilhã, e todos os
conhecimentos obtidos através desta experiência. São então referidas todas as caraterísticas
e particularidades inerentes ao trabalho diário de um Farmacêutico Comunitário.
This dissertation describes my professional experience to obtain a Master's degree in Pharmaceutical Sciences through two fields: Community Pharmacy and Research. Chapter I describes all the developed research. Biliary Atresia is the most frequent cause of neonatal cholestasis and the main reason for liver transplantation in children. The etiology of Biliary Atresia remains unknown and may represent a set of factors in association with the genetic and epigenetic constitution of patients. Considering a large number of references in the literature to environmental and epigenetic factors associated with pathophysiology, could there be a cause-effect relationship? This work aimed, through a systematic literature review, to integrate the information available in scientific studies on the role of epigenetic and environmental factors in the pathophysiology of Biliary Atresia and, eventually, more prevalent and described environmental epigenetic factors for the pathophysiology and appearance of the pathology in newborns. Although some investigation concerning epigenetics in Biliary Atresia have been reported, most were carried out in animal models, and further studies are needed to understand the factors and pathways acting in the pathology. Despite its pathophysiology of Biliary Atresia is complex and full of nuances, epigenetic (microRNAs and DNA methylation) and environmental (toxins and hypoxia) factors play an important role in Biliary Atresia, not only in its pathogenesis but also in the early diagnosis of the disease. Chapter II contains the Community Pharmacy Internship Report, which describes the internship experience at the São João Pharmacy, in Covilhã, and all the knowledge obtained through this experience. It reported the characteristics and particularities of the pharmacy and the daily work of a Community Pharmacist.
This dissertation describes my professional experience to obtain a Master's degree in Pharmaceutical Sciences through two fields: Community Pharmacy and Research. Chapter I describes all the developed research. Biliary Atresia is the most frequent cause of neonatal cholestasis and the main reason for liver transplantation in children. The etiology of Biliary Atresia remains unknown and may represent a set of factors in association with the genetic and epigenetic constitution of patients. Considering a large number of references in the literature to environmental and epigenetic factors associated with pathophysiology, could there be a cause-effect relationship? This work aimed, through a systematic literature review, to integrate the information available in scientific studies on the role of epigenetic and environmental factors in the pathophysiology of Biliary Atresia and, eventually, more prevalent and described environmental epigenetic factors for the pathophysiology and appearance of the pathology in newborns. Although some investigation concerning epigenetics in Biliary Atresia have been reported, most were carried out in animal models, and further studies are needed to understand the factors and pathways acting in the pathology. Despite its pathophysiology of Biliary Atresia is complex and full of nuances, epigenetic (microRNAs and DNA methylation) and environmental (toxins and hypoxia) factors play an important role in Biliary Atresia, not only in its pathogenesis but also in the early diagnosis of the disease. Chapter II contains the Community Pharmacy Internship Report, which describes the internship experience at the São João Pharmacy, in Covilhã, and all the knowledge obtained through this experience. It reported the characteristics and particularities of the pharmacy and the daily work of a Community Pharmacist.
Description
Keywords
Atresia Biliar Colestase Neonatal Epigenética Farmácia Comunitária Fatores Epigenéticos Genética