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Nanosystems in nose-to-brain drug delivery: a review of non-clinical brain targeting studies

2018Journal article Open access
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dc.contributor.authorPires, Patrícia C.
dc.contributor.authorSantos, Adriana O.
dc.date.accessioned2020-07-09T08:26:06Z
dc.date.available2020-07-09T08:26:06Z
dc.date.issued2018
dc.description.abstractThe treatment of neurodegenerative and psychiatric disorders remains a challenge in medical research. Several strategies have been developed over the years, either to overcome the blood-brain barrier or to achieve a safer or faster brain delivery, one of them being intranasal (IN) administration. The possibility of direct nose-to-brain transport offers enhanced targeting and reduced systemic side effects. Nevertheless, labile, low soluble, low permeant and/or less potent drugs might need a formulation other than the common solutions or suspensions. For that, the formulation of nanosystems is considered to be a promising approach, since it can protect drugs from chemical and/or metabolic degradation, enhance their solubility, or offer transport through biological membranes. However, the understanding of the factors promoting efficient brain targeting when using nanosystems through the nasal route is currently patchy and incomplete. The main purpose of the present review was to evaluate the association between brain delivery efficacy (in terms of brain targeting, brain bioavailability and time to reach the brain) and nanosystem type. For that, we performed a systematic bibliographic search and analysis. Furthermore, study designs, nanosystem properties, and reporting quality were also analyzed and discussed. It was found a high heterogeneity in how pre-clinical brain targeting studies have been conducted, analyzed and reported in scientific literature, which surely originates a significant degree of bias and data dispersion. This review attempts to provide some systematization recommendations, which may be useful for researchers entering the field, and assist in increasing the uniformity of future reports. The analysis of literature data confirmed that there is evidence of the advantage of the IN route (when compared to the intravenous route) and in using carrier nanosystems (when compared to IN solutions) for brain delivery of a large set of drugs. Among the most represented nanosystem classes, microemulsions had some of the lowest pharmacokinetic ratios values, while polymeric micelles had some of the best. Nevertheless, brain targeting efficacy comparisons between nanosystem groups had little statistical significance, and the superiority of the polymeric micelles group disappeared when nanosystems were compared to the respective IN drug solutions. In fact, some drugs reached the brain so efficiently, even as drug solutions, that further benefit from formulating them into nanosystems became less evident.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jconrel.2017.11.047pt_PT
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/10400.6/10337
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAdministration Intranasalpt_PT
dc.subjectAnimalspt_PT
dc.subjectBiological Transportpt_PT
dc.subjectBrainpt_PT
dc.subjectHumanspt_PT
dc.subjectNanostructurespt_PT
dc.subjectNasal Mucosapt_PT
dc.subjectDrug Delivery Systemspt_PT
dc.titleNanosystems in nose-to-brain drug delivery: a review of non-clinical brain targeting studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage100pt_PT
oaire.citation.startPage89pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume270pt_PT
oaire.fundingStream5876
person.familyNamePires
person.familyNameOliveira dos Santos
person.givenNamePatrícia
person.givenNameAdriana
person.identifier.ciencia-idDF1D-73CF-6BA4
person.identifier.ciencia-id891C-417A-1534
person.identifier.orcid0000-0003-0036-4894
person.identifier.orcid0000-0002-1224-9191
person.identifier.ridH-4597-2011
person.identifier.scopus-author-id14049212000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0516710a-fba9-41c5-9256-a1675e3fade8
relation.isAuthorOfPublicatione744a964-5bd5-4180-8ecb-1caead95c454
relation.isAuthorOfPublication.latestForDiscovery0516710a-fba9-41c5-9256-a1675e3fade8
relation.isProjectOfPublicationcb4688cf-40da-4197-9eb0-c55bad699ad3
relation.isProjectOfPublication.latestForDiscoverycb4688cf-40da-4197-9eb0-c55bad699ad3

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