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Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prostate cancer cell line

2013Journal article Open access
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dc.contributor.authorMamede, Ana Catarina Manjolinha
dc.contributor.authorAbrantes, Ana M
dc.contributor.authorPedrosa, L
dc.contributor.authorLopes, João Casalta
dc.contributor.authorPires, A S
dc.contributor.authorTeixo, R J
dc.contributor.authorGonçalves, A C
dc.contributor.authorRibeiro, A B Sarmento
dc.contributor.authorMaia, C J
dc.contributor.authorBotelho, M F
dc.date.accessioned2019-11-28T17:09:21Z
dc.date.available2019-11-28T17:09:21Z
dc.date.issued2013
dc.description.abstractProstate cancer (PCa) has a high incidence worldwide. One of the major causes of PCa resistance is intratumoral hypoxia. In solid tumors, hypoxia is strongly associated with malignant progression and resistance to therapy, which is an indicator of poor prognosis. The antiproliferative effect and induced death caused by doxorubicin, epirubicin, cisplatin, and flutamide in a hormone-independent PCa cell line will be evaluated. The hypoxia effect on drug resistance to these drugs, as well as cell proliferation and migration, will be also analyzed. All drugs induced an antiproliferative effect and also cell death in the cell line under study. Hypoxia made the cells more resistant to all drugs. Moreover, our results reveal that long time cell exposure to hypoxia decreases cellular proliferation and migration. Hypoxia can influence cellular resistance, proliferation, and migration. This study shows that hypoxia may be a key factor in the regulation of PCa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1155/2013/918207pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7640
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProstate cancerpt_PT
dc.titleBeyond the limits of oxygen: effects of hypoxia in a hormone-independent prostate cancer cell linept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleISRN Oncologypt_PT
oaire.citation.volume2013pt_PT
person.familyNameAbrantes
person.familyNameCasalta-Lopes
person.familyNameMaia Baptista
person.familyNameBotelho
person.givenNameAna M
person.givenNameJoão
person.givenNameCláudio Jorge
person.givenNameMaria Filomena
person.identifierR-000-10V
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierR-000-BFD
person.identifier.ciencia-id7818-2E25-9410
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idD716-3387-EAC1
person.identifier.orcid0000-0003-4185-7871
person.identifier.orcid0000-0001-5215-7542
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-7202-1650
person.identifier.ridG-6913-2018
person.identifier.ridG-1860-2011
person.identifier.scopus-author-id26029747600
person.identifier.scopus-author-id55128240300
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7005751167
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67a1671d-1c2c-4a42-ad0e-6213e203e560
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