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The importance of spheroids in analyzing nanomedicine efficacy

2020-06-18Journal article Open access
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dc.contributor.authorMó, Inês
dc.contributor.authorSabino, Ivo
dc.contributor.authorMelo-Diogo, Duarte de
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorAlves, Cátia
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-07-27T15:33:21Z
dc.date.available2022-07-27T00:30:22Z
dc.date.issued2020-06-18
dc.description.abstractThe use of nanomedicines for cancer treatment holds a great potential due to their improved efficacy and safety. During the nanomedicine preclinical in vitro evaluation stage, these are mainly tested on cell culture monolayers. However, these 2D models are an unrealistic representation of the in vivo tumors, leading to an inaccurate screening of the candidate formulations. To address this problem, spheroids are emerging as an additional tool to validate the efficacy of new therapeutics due to the ability of these 3D in vitro cancer models to mimic the key features displayed by in vivo solid tumors. In this review, the application of spheroids for the evaluation of nanomedicines' physicochemical properties and therapeutic efficacy is discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2217/nnm-2020-0054pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10380
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Medicinept_PT
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.subject2D in vitro modelspt_PT
dc.subject3D modelspt_PT
dc.subjectCancer - Oncologypt_PT
dc.subjectNanomaterialspt_PT
dc.subjectSpheroidspt_PT
dc.subjectTherapeuticspt_PT
dc.titleThe importance of spheroids in analyzing nanomedicine efficacypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.endPage1525pt_PT
oaire.citation.issue15pt_PT
oaire.citation.startPage1513pt_PT
oaire.citation.titleNanomedicinept_PT
oaire.citation.volume15pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameMó
person.familyNameSabino
person.familyNameMiguel de Melo Diogo
person.familyNameSousa
person.familyNameAlves
person.familyNameJoaquim Sobreira Correia
person.givenNameInês
person.givenNameIvo
person.givenNameDuarte
person.givenNameAna Rita Lima
person.givenNameCátia Gomes
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id5316-B64E-938E
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person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5591-0891
person.identifier.orcid0000-0002-9185-2342
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCedi os copyrights à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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