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Abstract(s)
O presente Relatório aqui apresentado divide-se em três partes: uma correspondente à
componente de investigação e duas relativas às componentes de estágios em farmácia hospitalar
e em farmácia comunitária.
O primeiro capítulo aborda a componente de investigação, realizada no Centro de Investigação
em Ciências da Saúde da Universidade da Beira Interior. O estudo teve como objetivo o
desenvolvimento de uma emulsão cosmética O/A com Ulva lactuca para a Dermatite Atópica.
A Dermatite Atópica (DA) é uma doença inflamatória crónica da pele cujo controlo torna
necessário recorrer à utilização de produtos cosméticos. Com vista a incorporar extratos de algas
como ingredientes cosméticos, o trabalho desta dissertação avaliou as propriedades de quatro
extratos da alga Ulva lactuca, relativamente à sua biocompatibilidade in vitro com células da pele
através de um ensaio MTT, poder antioxidante através de um ensaio de DPPH e poder reparador
da pele com recurso a um ensaio de migração. Os resultados demonstraram que o extrato
etanólico a 40% foi o mais biocompatível, o metanólico o que demonstrou maior poder
cicatrizante e que todos demonstraram fraca atividade antioxidante. Paralelamente, desenvolveuse uma emulsão com ingredientes com ações benéficas na DA, com vista à incorporação de um
dos extratos. O protótipo escolhido foi formulado a quente. O produto final foi sujeito a testes de
estabilidade acelerada encontrando-se a 400C durante 3 meses, quando apresentou alteração da
cor e manutenção das restantes características organoléticas. Concluiu-se que estes extratos de
algas podem apresentar potencial aplicação cosmética graças à sua baixa toxicidade celular e ao
seu poder cicatrizante.
O segundo capítulo refere-se à experiência profissionalizante em farmácia hospitalar, cujo estágio
decorreu na Unidade Local de Saúde Cova da Beira, durante o período de tempo compreendido
entre 5 de fevereiro e 29 de março de 2024.
O terceiro capítulo refere-se se à experiência profissionalizante em farmácia comunitária, cujo
estágio decorreu na farmácia São Cosme, durante o período de tempo compreendido entre 1 de
abril e 21 de junho de 2024. Nos capítulos 2 e 3 serão apontadas as atividades realizadas, assim
como o conhecimento adquirido ao longo dos períodos correspondentes aos estágios curriculares
mencionados anteriormente.
This report is divided into three parts: one corresponding to the research component and two related to the internship components in hospital pharmacy and community pharmacy. The first chapter addresses the research component, carried out at the Health Sciences Research Center of the University of Beira Interior. The study aimed to develop an O/W cosmetic emulsion with Ulva lactuca for Atopic Dermatitis. Atopic Dermatitis (AD) is a chronic inflammatory skin disease and its control requires the use of cosmetic products. In order to incorporate algae extracts as cosmetic ingredients, this dissertation evaluated the properties of four extracts of the Ulva lactuca algae, regarding their in vitro biocompatibility with skin cells through an MTT test, antioxidant power through a DPPH test and skin repair power using a migration test. The results showed that the 40% ethanolic extract was the most biocompatible, the methanolic extract demonstrated the greatest healing power and that all of them demonstrated weak antioxidant activity. At the same time, an emulsion was developed with ingredients that have beneficial effects on AD, with the objetive to incorporate one of the extracts. The chosen prototype was formulated in a hot state. The final product was subjected to acelerated stability tests at 40°C for 3 months, when it showed a change in colour but maintained its remaining organoleptic characteristics. It was concluded that seaweed extracts may have potential due to their low cellular toxicity and healing power. The second chapter refers to the professional experience in hospital pharmacy and the internship took place at the Cova da Beira Local Health Unit, during the period between February 5 and March 29, 2024. The third chapter refers to the professional experience in community pharmacy and the internship took place at the São Cosme pharmacy, during the period between April 1 and June 21, 2024. Chapters 2 and 3 will highlight the activities carried out, as well as the knowledge acquired throughout the periods corresponding to the curricular internships mentioned above.
This report is divided into three parts: one corresponding to the research component and two related to the internship components in hospital pharmacy and community pharmacy. The first chapter addresses the research component, carried out at the Health Sciences Research Center of the University of Beira Interior. The study aimed to develop an O/W cosmetic emulsion with Ulva lactuca for Atopic Dermatitis. Atopic Dermatitis (AD) is a chronic inflammatory skin disease and its control requires the use of cosmetic products. In order to incorporate algae extracts as cosmetic ingredients, this dissertation evaluated the properties of four extracts of the Ulva lactuca algae, regarding their in vitro biocompatibility with skin cells through an MTT test, antioxidant power through a DPPH test and skin repair power using a migration test. The results showed that the 40% ethanolic extract was the most biocompatible, the methanolic extract demonstrated the greatest healing power and that all of them demonstrated weak antioxidant activity. At the same time, an emulsion was developed with ingredients that have beneficial effects on AD, with the objetive to incorporate one of the extracts. The chosen prototype was formulated in a hot state. The final product was subjected to acelerated stability tests at 40°C for 3 months, when it showed a change in colour but maintained its remaining organoleptic characteristics. It was concluded that seaweed extracts may have potential due to their low cellular toxicity and healing power. The second chapter refers to the professional experience in hospital pharmacy and the internship took place at the Cova da Beira Local Health Unit, during the period between February 5 and March 29, 2024. The third chapter refers to the professional experience in community pharmacy and the internship took place at the São Cosme pharmacy, during the period between April 1 and June 21, 2024. Chapters 2 and 3 will highlight the activities carried out, as well as the knowledge acquired throughout the periods corresponding to the curricular internships mentioned above.
Description
Keywords
Poder Reparador da Pele Algas Atividade Antioxidante Dermatite Atópica Farmácia Comunitária Farmácia Hospitalar Fibroblastos Formulação Ulva Lactuca Viabilidade Celular