| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.71 MB | Adobe PDF |
Authors
Abstract(s)
O presente relatório de estágio surge no âmbito da Unidade Curricular “Estágio” do
Mestrado Integrado em Ciências Farmacêuticas, encontrando-se subdividido em três
capítulos.
O primeiro capítulo refere-se à componente de investigação e intitula-se “A amostra de
suor em Workplace Drug Testing”. Workplace Drug Testing é uma área bem
estabelecida da toxicologia forense, cujo objetivo primordial consiste na redução dos
acidentes de trabalho causados por trabalhadores sob efeitos de substâncias
incapacitantes, recorrendo para tal à sua deteção. Apesar de ser uma prática bem
instituída nos Estados Unidos, na Europa o mesmo não acontece, sendo por isso,
necessário implementar medidas que assegurem um padrão de qualidade homogéneo e
juridicamente seguro. Foi com este objetivo que foi fundada a European Workplace
Drug Testing Society, em 1998. A amostra de suor como matriz biológica para a deteção
de substâncias de abuso tem demonstrado um interesse crescente no campo da
toxicologia, devido às inúmeras vantagens que apresenta quando comparada com as
amostras tradicionais sangue e urina. Para uma avaliação integral desta matriz, esta
revisão explora conceitos desde os mecanismos fisiológicos de excreção de suor; a
deposição de xenobióticos nesta amostra; vantagens e desvantagens da sua utilização na
análise de substâncias de abuso; métodos de colheita e metodologias de análise. Foi
efetuada uma pesquisa nas bases de dados Pubmed, Scientific Electronic Library Online,
Web of Science e Scopus, de onde foram selecionados 50 artigos para integrarem esta
revisão. Dos artigos selecionados pode-se concluir que o suor é uma mais-valia enquanto
amostra alternativa para deteção de substâncias de abuso no contexto de Workplace
Drug Testing, porém mais estudos são necessários de forma que a sua implementação
seja uma realidade homogénea e regulamentada.
No segundo capítulo descreve-se o conhecimento adquirido e as atividades
desenvolvidas durante o estágio em Farmácia Comunitária, realizado na Farmácia
Taborda, no Fundão, no período de 7 de fevereiro a 30 de abril de 2022, sob orientação
da Dr.ª Cristina Almiro.
Por último, no terceiro capítulo resume-se a experiência e aprendizagem obtida ao longo
do estágio em Farmácia Hospitalar, realizado nos Serviços Farmacêuticos do Centro
Hospitalar Universitário Cova da Beira, na Covilhã, entre 2 de maio e 17 de junho de
2022, sob orientação da Dr.ª Olímpia Fonseca.
The present report summarizes the developed activities within the scope of the curricular unit “Internship” of the Integrated Master’s Degree in Pharmaceutical Sciences, at the University of Beira Interior, and is divided into three chapters. The first chapter refers to the research component entitled “The sweat sample in Workplace Drug Testing”. Workplace Drug Testing is a well-established area of forensic toxicology, and its aim is to reduce accidents caused by workers who are under the influence of impairing substances. Despite of being a widely used practice in the United States, the same does not occur in Europe. It is therefore necessary to implement measures to ensure a homogenous and legally secured standard of quality. It was for this purpose that the European Workplace Drug Testing Society was founded in 1998. The sweat sample as a biological matrix for the detection of substances of abuse has been of growing interest in the field of toxicology due to its numerous advantages when compared to the traditional samples, blood and urine. For a holistic evaluation of this matrix, this review explores concepts from the physiological mechanisms of sweat excretion; the deposition of xenobiotics; advantages and disadvantages of its use in the analysis of substance of abuse; collection methods and methodologies of analysis. The present research was carried out using the Pubmed, Scientific Electronic Library Online, Web of Sciences and Scopus databases, from which 50 articles were selected for this review. From the selected articles it can be concluded that sweat has an added value as an alternative sample for the detection of abuse substances in the context of Workplace Drug Testing. However, more studies are needed, so that its regulated implementation becomes a reality. Chapter two describes the knowledge acquired and the activities developed during the internship in Community Pharmacy at Taborda Pharmacy, Fundão, between February 7th and the 30th of April of 2022, under the guidance of Dr.ª Cristina Almiro. The third chapter is a summary of the experience and learning acquired during the internship in Hospital Pharmacy, at Centro Hospitalar Universitário Cova da Beira, in Covilhã, between May 2nd and June 17th of 2022, under the guidance of Dr.ª Olímpia Fonseca.
The present report summarizes the developed activities within the scope of the curricular unit “Internship” of the Integrated Master’s Degree in Pharmaceutical Sciences, at the University of Beira Interior, and is divided into three chapters. The first chapter refers to the research component entitled “The sweat sample in Workplace Drug Testing”. Workplace Drug Testing is a well-established area of forensic toxicology, and its aim is to reduce accidents caused by workers who are under the influence of impairing substances. Despite of being a widely used practice in the United States, the same does not occur in Europe. It is therefore necessary to implement measures to ensure a homogenous and legally secured standard of quality. It was for this purpose that the European Workplace Drug Testing Society was founded in 1998. The sweat sample as a biological matrix for the detection of substances of abuse has been of growing interest in the field of toxicology due to its numerous advantages when compared to the traditional samples, blood and urine. For a holistic evaluation of this matrix, this review explores concepts from the physiological mechanisms of sweat excretion; the deposition of xenobiotics; advantages and disadvantages of its use in the analysis of substance of abuse; collection methods and methodologies of analysis. The present research was carried out using the Pubmed, Scientific Electronic Library Online, Web of Sciences and Scopus databases, from which 50 articles were selected for this review. From the selected articles it can be concluded that sweat has an added value as an alternative sample for the detection of abuse substances in the context of Workplace Drug Testing. However, more studies are needed, so that its regulated implementation becomes a reality. Chapter two describes the knowledge acquired and the activities developed during the internship in Community Pharmacy at Taborda Pharmacy, Fundão, between February 7th and the 30th of April of 2022, under the guidance of Dr.ª Cristina Almiro. The third chapter is a summary of the experience and learning acquired during the internship in Hospital Pharmacy, at Centro Hospitalar Universitário Cova da Beira, in Covilhã, between May 2nd and June 17th of 2022, under the guidance of Dr.ª Olímpia Fonseca.
Description
Keywords
Farmácia
Hospitalar Farmácia Comunitária Substâncias de Abuso Suor Workplace Drug Testing