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Bilateral theta-burst magnetic stimulation influence on event-related brain potentials

dc.contributor.authorPinto, Nuno
dc.contributor.authorDuarte, Marta
dc.contributor.authorGonçalves, Helena
dc.contributor.authorSilva, Ricardo
dc.contributor.authorGama, Jorge
dc.contributor.authorPatto, Maria Da Assunção Vaz
dc.date.accessioned2020-02-06T10:40:32Z
dc.date.available2020-02-06T10:40:32Z
dc.date.issued2018-01
dc.description.abstractTheta-burst stimulation (TBS) can be a non-invasive technique to modulate cognitive functions, with promising therapeutic potential, but with some contradictory results. Event related potentials are used as a marker of brain deterioration and can be used to evaluate TBS-related cognitive performance, but its use remains scant. This study aimed to study bilateral inhibitory and excitatory TBS effects upon neurocognitive performance of young healthy volunteers, using the auditory P300' results. Using a double-blind sham-controlled study, 51 healthy volunteers were randomly assigned to five different groups, two submitted to either excitatory (iTBS) or inhibitory (cTBS) stimulation over the left dorsolateral pre-frontal cortex (DLPFC), two other actively stimulated the right DLPFC and finally a sham stimulation group. An oddball based auditory P300 was performed just before a single session of iTBS, cTBS or sham stimulation and repeated immediately after. P300 mean latency comparison between the pre- and post-TBS stimulation stages revealed significantly faster post stimulation latencies only when iTBS was performed on the left hemisphere (p = 0.003). Right and left hemisphere cTBS significantly delayed P300 latency (right p = 0.026; left p = 0.000). Multiple comparisons for N200 showed slower latencies after iTBS over the right hemisphere. No significant difference was found in amplitude variation. TBS appears to effectively influence neural networking involved in P300 formation, but effects seem distinct for iTBS vs cTBS and for the right or the left hemisphere. P300 evoked potentials can be an effective and practical tool to evaluate transcranial magnetic stimulation related outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1371/journal.pone.0190693pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9053
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectBrainpt_PT
dc.subjectDouble-Blind Methodpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectReaction Timept_PT
dc.subjectTranscranial Magnetic Stimulationpt_PT
dc.subjectYoung Adultpt_PT
dc.subjectEvent-Related Potentials, P300pt_PT
dc.titleBilateral theta-burst magnetic stimulation influence on event-related brain potentialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPagee0190693pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume13pt_PT
person.familyNameCardoso Pinto
person.familyNameDuarte
person.familyNameReis Gama
person.familyNamePatto
person.givenNameNuno Filipe
person.givenNameMarta
person.givenNameJorge Manuel
person.givenNameMaria Da Assunção Vaz
person.identifierT-9700-2018
person.identifier.ciencia-idB918-0196-0C1E
person.identifier.ciencia-idE81F-1C44-F08D
person.identifier.ciencia-idB211-AE80-2B00
person.identifier.orcid0000-0002-6605-2407
person.identifier.orcid0000-0001-6720-3169
person.identifier.orcid0000-0003-3926-580X
person.identifier.orcid0000-0002-0653-3428
person.identifier.ridA-1091-2017
person.identifier.scopus-author-id55866548000
person.identifier.scopus-author-id11240264600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication39d93839-cbb1-4c39-a5b1-d43c97997d6d
relation.isAuthorOfPublication5edfb7cf-56e9-45aa-ae58-56eb1893809f
relation.isAuthorOfPublication4b605a0e-d32e-4d60-9e39-0290f57c3ff6
relation.isAuthorOfPublicationb9406509-2749-472c-b9ea-fe944f89283b
relation.isAuthorOfPublication.latestForDiscovery39d93839-cbb1-4c39-a5b1-d43c97997d6d

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