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Silica Aerogel-Polycaprolactone Scaffolds for Bone Tissue Engineering

2023-06-14Journal article Open access
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dc.contributor.authorPontinha, Ana
dc.contributor.authorMoreira, Eliana Barbosa Da Silva
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorMelo-Diogo, Duarte de
dc.contributor.authorCorreia, I.J.
dc.contributor.authorAlves, Patrícia
dc.date.accessioned2023-12-18T14:07:31Z
dc.date.available2023-12-18T14:07:31Z
dc.date.issued2023-06-14
dc.description.abstractSilica aerogel is a material composed of SiO2 that has exceptional physical properties when utilized for tissue engineering applications. Poly-ε-caprolactone (PCL) is a biodegradable polyester that has been widely used for biomedical applications, namely as sutures, drug carriers, and implantable scaffolds. Herein, a hybrid composite of silica aerogel, prepared with two different silica precursors, tetraethoxysilane (TEOS) or methyltrimethoxysilane (MTMS), and PCL was synthesized to fulfil bone regeneration requirements. The developed porous hybrid biocomposite scaffolds were extensively characterized, regarding their physical, morphological, and mechanical features. The results showed that their properties were relevant, leading to composites with different properties. The water absorption capacity and mass loss were evaluated as well as the influence of the different hybrid scaffolds on osteoblasts’ viability and morphology. Both hybrid scaffolds showed a hydrophobic character (with water contact angles higher than 90°), low swelling (maximum of 14%), and low mass loss (1–7%). hOB cells exposed to the different silica aerogel-PCL scaffolds remained highly viable, even for long periods of incubation (7 days). Considering the obtained results, the produced hybrid scaffolds may be good candidates for future application in bone tissue engineering.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms241210128pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13832
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.relationSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/12/10128pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTissue engineeringpt_PT
dc.subjectSilica aerogelpt_PT
dc.subjectHybrid compositespt_PT
dc.subjectPoly-ε-caprolactone (PCL)pt_PT
dc.titleSilica Aerogel-Polycaprolactone Scaffolds for Bone Tissue Engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemical Process Engineering and Forest Products Research Centre
oaire.awardTitleSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00102%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.02495.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.06320.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.06044.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage10128pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume24pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamCEEC IND4ed
person.familyNameRodrigues Pontinha
person.familyNameMoreira
person.familyNameLopes Melo
person.familyNameMiguel de Melo Diogo
person.familyNameJoaquim Sobreira Correia
person.familyNameAlves
person.givenNameAna Dora
person.givenNameEliana Barbosa da Silva
person.givenNameBruna Daniela
person.givenNameDuarte
person.givenNameIlídio
person.givenNamePatrícia
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
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person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id341B-551C-19FD
person.identifier.orcid0000-0002-0400-4645
person.identifier.orcid0000-0002-5933-1766
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-8943-8329
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id12762379800
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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