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Optimization of gold core-mesoporous silica shell functionalization with TPGS and PEI for cancer therapy

2019-03-28Journal article Open access
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dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorReis, Catarina A.
dc.contributor.authorMoreira, André
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-05-22T16:19:09Z
dc.date.available2021-05-22T00:30:12Z
dc.date.issued2019-03-28
dc.description.abstractPhotothermal therapy (PTT) has captured the attention of different researchers around the world, since the application of NIR light responsive-nanomaterials has shown promising results in cancer therapy. Gold-core mesoporous silica shell (Au-MSS) nanoparticles allow the combination of gold mediated PTT with the drug delivery in order to improve their therapeutic potential. In this study, two different methodologies, electrostatic or chemical linkage, were explored to functionalize Au-MSS nanorods with TPGS and PEI. For that purpose, the TPGS and PEI were chemically coupled to each other or modified with 3-(triethoxysilyl)propyl isocyanate. The produced Au-MSS nanorods display a uniform morphology and a well-defined gold nucleus and silica shell. Further, the particles surface charge was dependent on the synthesis methodology. The particles modified by electrostatic interactions (Au-MSS/TPGS-PEI) were slightly negative (−16.9 and −5.1 mV) whereas the formulations produced by chemical linkage (Au-MSS/TPGS/PEI) resulted in positively charged nanoparticles (30.9 and 6.8 mV). The successful incorporation of the polymers was confirmed by Fourier Transformed Infrared spectroscopy and thermogravimetric analysis. Moreover, the Au-MSS functionalization did not affect the particles PTT capacity. However, the Au-MSS/TPGS/PEI nanorods displayed a decreased drug encapsulation efficiency. In vitro assays demonstrated the cytocompatibility of Au-MSS up to concentrations of 200 μg/mL, however the positively charged formulations only remained biocompatible until 100 and 125 μg/mL. Overall, the attained data confirm the successful modification of Au-MSS nanorods with TPGS and PEI as well as their applicability as PTT and drug delivery agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.micromeso.2019.04.064pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7093
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1387181119302914?via%3Dihubpt_PT
dc.subjectGold core silica shell nanorodspt_PT
dc.subjectTPGSpt_PT
dc.subjectPEIpt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectCancerpt_PT
dc.titleOptimization of gold core-mesoporous silica shell functionalization with TPGS and PEI for cancer therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMicroporous and Mesoporous Materialspt_PT
oaire.citation.volume285pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameFélix Rodrigues
person.familyNameMoreira
person.familyNameCalvinho
person.familyNameCorreia
person.givenNameAna Carolina
person.givenNameAndré Ferreira
person.givenNamePaula Cristina Nunes Ferreira
person.givenNameIlídio Joaquim Sobreira
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos da publicação foram cedidos à editora.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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