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HA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer-targeted photothermal and chemotherapy

2021-12-02Journal article Open access
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dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorFernandes, Natanael
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.contributor.authorMoreira, André
dc.date.accessioned2023-01-04T15:40:45Z
dc.date.available2025-01-04T01:30:20Z
dc.date.issued2021-12-02
dc.description.abstractAims: To develop a tumor-targeted chemo-photothermal nanomedicine through the functionalization of acridine orange (AO)-loaded gold-core mesoporous silica shell (AuMSS) nanorods with polyethylenimine (PEI) and hyaluronic acid (HA). Methods: Functionalization of the AuMSS nanorods was achieved through the chemical linkage of PEI followed by electrostatic adsorption of HA. Results: HA functionalization improved AuMSS' cytocompatibility by decreasing blood hemolysis, and PEI-HA inclusion promoted a controlled and sustained AO release. In vitro assays revealed that HA functionalization increased the internalization of nanoparticles by human negroid cervix epithelioid carcinoma cancer (HeLa) cells, and the combinatorial treatment mediated by AuMSS/PEI/HA_AO nanorods presented an enhanced effect, with >95% of cellular death. Conclusion: AuMSS/PEI/HA_AO formulations can act as tumor-targeted chemo-photothermal nanomedicines for the combinatorial therapy of cervical cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2217/nnm-2021-0270pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12582
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Medicinept_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
dc.subjectPhotothermal therapypt_PT
dc.subjectPolyethyleniminept_PT
dc.subjectHyaluronic acidpt_PT
dc.subjectGold-core silica shell nanoparticlespt_PT
dc.subjectAcridine orangept_PT
dc.subjectCancerpt_PT
dc.titleHA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer-targeted photothermal and chemotherapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT
oaire.citation.conferencePlaceLondonpt_PT
oaire.citation.endPage2586pt_PT
oaire.citation.issue29pt_PT
oaire.citation.startPage2569pt_PT
oaire.citation.titleNanomedicinept_PT
oaire.citation.volume16pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFélix Rodrigues
person.familyNameFernandes
person.familyNameMiguel de Melo Diogo
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameJoaquim Sobreira Correia
person.familyNameMoreira
person.givenNameAna Carolina
person.givenNameNatanael
person.givenNameDuarte
person.givenNamePaula
person.givenNameIlídio
person.givenNameAndré Ferreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier1161643
person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2315-CC5A-3DBB
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-7737-9288
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-0604-2506
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56401521300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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