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Abstract(s)
Introdução: A doença renal crónica tem uma prevalência em constante crescimento, estimando-se cerca de 265 milhões de pessoas em todo o mundo com risco aumentado para desenvolver esta doença. Os doentes renais crónicos no estadio mais avançado da doença apresentam um risco 10 a 30 vezes superior do que a população em geral de morrer por doença cardio-vascular. Objectivos: Aprofundar o conhecimento actual sobre a insuficiência renal crónica e a sua relação com a doença cardio-vascular. Métodos: Pesquisa bibliográfica na base de dados electrónica “PubMed”, com as seguintes palavras-chave: "chronickidneydisease", "glomerular filtration rate", "GFR", "eGFR", como pesquisa para doença renal crónica, e "cardiovascular disease" e "stroke", como pesquisa para doença cardio-vascular.Também se utilizou informação presente em diversos websites nacionais e internacionais. Conclusões: A doença renal crónica aumenta o risco de desenvolver doença-cardiovascular, em especial a hipertrofia ventricular esquerda, a doença coronária e o acidente vascular cerebral. Também se encontra relacionada com o desenvolvimento de lesões cerebrais, tais como lesões da substância branca, enfartes cerebrais silenciosos e atrofia cerebral. O consumo de pequenas quantidades de álcool, desde 7 gramas de etanol por semana, torna-se altamente prejudicial a estes doentes, pois aumentam o risco para desenvolver acidentes vasculares cerebrais. Além disto, concluiu-se que apesar do método indicado actualmente para avaliar a função renal ser através da equação CKD-EPI, utilizando a concentração sérica de creatinina, sexo, idade e raça, a maioria dos médicos continuam a utilizar a concentração sérica da creatinina isoladamente, o método menos preciso e que pode levar a que 50% dos idosos com doença renal crónica estadio 3 não sejam diagnosticados.
Introduction: Chronic kidney disease has its prevalence in constant growth, estimating 265 million people around the world with increased risk for developing this disease. People with chronic kidney disease in its later stage have 10 to 30 times increased risk to die from cardiovascular diseases than the general population. Objectives: Deepen the current knowledge about chronic kidney disease and its relation with cardiovascular disease. Methods: Bibliographic search in the electronic database “PubMed”, with the following keywords: “chronic kidney disease”, “glomerular filtration rate”, "GFR", "eGFR", as search terms for chronic kidney disease, and "cardiovascular disease" e "stroke" as terms for cardiovascular disease. Several Portuguese and international websites were used too. Conclusions: Chronic kidney disease increases the risk for developing cardiovascular disease, in particular left ventricular hypertrophy, coronarian disease and stroke. It is also related with the presence of brain lesions, such as white matter lesions, silent brain infarcts and brain atrophy. Even little alcohol consumption, i.e. 7 grams of ethanol per week, is highly prejudicial to patients with chronic kidney disease, because it increases their risk to have a stroke. Furthermore, although the current recommended way to evaluate renal function is by applying CKD-EPI equation, which uses patient serum creatinine concentration, age, sex and race, most medical personnel still uses serum creatinine concentration at its own, which can result in about 50% percent of old people with stage 3 chronic kidney disease not being diagnosed.
Introduction: Chronic kidney disease has its prevalence in constant growth, estimating 265 million people around the world with increased risk for developing this disease. People with chronic kidney disease in its later stage have 10 to 30 times increased risk to die from cardiovascular diseases than the general population. Objectives: Deepen the current knowledge about chronic kidney disease and its relation with cardiovascular disease. Methods: Bibliographic search in the electronic database “PubMed”, with the following keywords: “chronic kidney disease”, “glomerular filtration rate”, "GFR", "eGFR", as search terms for chronic kidney disease, and "cardiovascular disease" e "stroke" as terms for cardiovascular disease. Several Portuguese and international websites were used too. Conclusions: Chronic kidney disease increases the risk for developing cardiovascular disease, in particular left ventricular hypertrophy, coronarian disease and stroke. It is also related with the presence of brain lesions, such as white matter lesions, silent brain infarcts and brain atrophy. Even little alcohol consumption, i.e. 7 grams of ethanol per week, is highly prejudicial to patients with chronic kidney disease, because it increases their risk to have a stroke. Furthermore, although the current recommended way to evaluate renal function is by applying CKD-EPI equation, which uses patient serum creatinine concentration, age, sex and race, most medical personnel still uses serum creatinine concentration at its own, which can result in about 50% percent of old people with stage 3 chronic kidney disease not being diagnosed.
Description
Keywords
Doença renal crónica Doença renal crónica - Doença cardio-vascular
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Citation
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Universidade da Beira Interior