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Abstract(s)
O trabalho apresentado neste documento encontra-se dividido em três capítulos, que correspondem às três vertentes abordadas no decurso do estágio final do Mestrado Integrado em Ciências Farmacêuticas.
O primeiro capítulo refere-se à experiência profissional desenvolvido no Centro Hospitalar Vila Nova de Gaia/Espinho. Neste capítulo, tendo por base o Manual de Boas Praticas e considerando a legislação em vigor, estão descritas as atividades realizadas e as competências adquiridas no decurso do estágio realizado nas diversas áreas dos serviços farmacêuticos.
No segundo capítulo é abordada a experiência profissional adquirida durante o estágio curricular realizado na Farmácia Popular, situada na localidade do Tortosendo, concelho da Covilhã. De um modo semelhante, procede-se à descrição das atividades efetuadas e de todos os conhecimentos e competências adquiridas durante o estágio.
No terceiro capítulo encontra-se descrito o trabalho de investigação desenvolvido no Centro de Investigação em Ciências da Saúde durante o último ano. Este envolveu a síntese e a avaliação biológica de esteróides da série pregnano com potencial atividade antiproliferativa. Neste âmbito, explorou-se a reação de Michael obtendo-se um novo processo reacional, utilizando micro-ondas e o catalisador Bi(OTf)3, que permitiu obter a 5α-indoleprogesterona. Após alguns estudos sobre a reatividade da reação, avaliou-se o efeito antiproliferativo do produto obtido e da progesterona.
The work presented in this paper is divided into three chapters, which correspond to the three aspects discussed during the final stage of the Master degree in Pharmaceutical Sciences. The first chapter refers to the experience developed in the Centro Hospitalar Vila Nova de Gaia/Espinho. In this chapter, based on the Manual of Good Practices and considering the legislation, are described the activities and skills acquired during the training held in various areas of the pharmaceutical service. The second chapter discussed the experience acquired during the internship held in Farmácia Popular, located in Tortosendo, municipality of Covilhã. Similarly, the activities carried out as well as all the knowledge and skills acquired during the internship in the community pharmacy are described in this chapter. The third chapter describes the research work lead at the Center for Research in Health Sciences during the last year. This involved the synthesis and biological evaluation of steroids from the pregnane series with potential antiproliferative activity. In this context, we explored the Michael reaction resulting in a new reaction process, using microwave and the catalyst Bi(OTf)3, to obtain 5α-indoleprogesterona. After a few studies about the reactivity of the reaction, the antiproliferative effect of the product and progesterone was evaluated.
The work presented in this paper is divided into three chapters, which correspond to the three aspects discussed during the final stage of the Master degree in Pharmaceutical Sciences. The first chapter refers to the experience developed in the Centro Hospitalar Vila Nova de Gaia/Espinho. In this chapter, based on the Manual of Good Practices and considering the legislation, are described the activities and skills acquired during the training held in various areas of the pharmaceutical service. The second chapter discussed the experience acquired during the internship held in Farmácia Popular, located in Tortosendo, municipality of Covilhã. Similarly, the activities carried out as well as all the knowledge and skills acquired during the internship in the community pharmacy are described in this chapter. The third chapter describes the research work lead at the Center for Research in Health Sciences during the last year. This involved the synthesis and biological evaluation of steroids from the pregnane series with potential antiproliferative activity. In this context, we explored the Michael reaction resulting in a new reaction process, using microwave and the catalyst Bi(OTf)3, to obtain 5α-indoleprogesterona. After a few studies about the reactivity of the reaction, the antiproliferative effect of the product and progesterone was evaluated.
Description
Keywords
Farmácia hospitalar - Gestão - Estágio pedagógico Farmácia comunitária - Gestão - Estágio pedagógico Reacção de Michael Esteróides
Pedagogical Context
Citation
Publisher
Universidade da Beira Interior