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Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

2018Journal article Open access
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dc.contributor.authorAdlhart, Christian
dc.contributor.authorVerran, J.
dc.contributor.authorAzevedo, Nuno Filipe
dc.contributor.authorOlmez, H.
dc.contributor.authorKeinanen-Toivola, Minna
dc.contributor.authorGouveia, Isabel C.
dc.contributor.authorMelo, Luis
dc.contributor.authorCrijns, F.
dc.date.accessioned2019-11-04T11:21:42Z
dc.date.available2019-11-04T11:21:42Z
dc.date.issued2018
dc.description.abstractThe spread of infections in healthcare environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (e.g. implants, catheters), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc., or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. This review addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated with the implementation of such anticontamination measures. Different chemistry-based approaches are discussed, for instance anti-adhesive surfaces (e.g. superhydrophobic, zwitterions), contact-killing surfaces (e.g. polymer brushes, phages), and biocide-releasing surfaces (e.g. triggered release, quorum sensing-based systems). The review also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (e.g. toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability) when developing and implementing antimicrobial surfaces.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jhin.2018.01.018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7490
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCross Infectionpt_PT
dc.subjectDisease Transmissionpt_PT
dc.subjectDisinfectantspt_PT
dc.subjectHumanspt_PT
dc.subjectEnvironmental Microbiologypt_PT
dc.subjectHealth Facilitiespt_PT
dc.subjectSurface Propertiespt_PT
dc.subjectInfectiouspt_PT
dc.titleSurface modifications for antimicrobial effects in the healthcare setting: a critical overviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage249pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage239pt_PT
oaire.citation.titleJournal of Hospital Infectionpt_PT
oaire.citation.volume99pt_PT
person.familyNameAdlhart
person.familyNameAzevedo
person.familyNameKeinanen-Toivola
person.familyNameGouveia
person.familyNameMelo
person.givenNameChristian
person.givenNameNuno Filipe
person.givenNameMinna
person.givenNameIsabel Cristina
person.givenNameLuis
person.identifiernf1BfwgAAAAJ&hl
person.identifier626131
person.identifier1534588
person.identifier.ciencia-idBE1B-918B-A853
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.ciencia-idE91A-5EBA-D64C
person.identifier.orcid0000-0002-4081-221X
person.identifier.orcid0000-0001-5864-3250
person.identifier.orcid0000-0002-1398-1480
person.identifier.orcid0000-0003-3290-9529
person.identifier.orcid0000-0002-8469-4462
person.identifier.ridK-1651-2014
person.identifier.ridF-8119-2011
person.identifier.scopus-author-id8092231700
person.identifier.scopus-author-id24328741500
person.identifier.scopus-author-id35508399600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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