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Abstract(s)
Introdução: A Diabetes Mellitus sendo uma doença crónica e cuja prevalência tem aumentado não só em Portugal como também a nível global torna-se importante perceber qual o seu impacto na superfície ocular. Diversos estudos têm analisado as alterações oculares provocadas pela Diabetes Mellitus, sendo que a retinopatia diabética é a 5ª maior causa de cegueira a nível global. No entanto, como as alterações no segmento anterior permanecem desvalorizadas comparativamente com as do segmento posterior no olho diabético, um dos objetivos deste estudo consiste na quantificação morfológica do endotélio corneal em indivíduos com Diabetes Mellitus tipo 2 para três zonas corneais (central, paracentral e periférica). Por último, outro dos objetivos deste trabalho é perceber se existe correlação entre os fatores de risco associados à diabetes e as alterações ao nível do endotélio corneal.
Metodologia: Ambos os grupos em estudo, diabéticos e não diabéticos, assinaram um consentimento informado e foram sujeitos a avaliação prévia incluindo biomicroscopia, medição da pressão intraocular e retinografia. A análise morfológica do endotélio corneal consistiu na quantificação da densidade celular endotelial, da área celular média, do coeficiente de variação e da hexagonalidade das células endoteliais. Estes parâmetros foram obtidos para três zonas da córnea: zona central, zona paracentral e zona periférica.
Resultados: Relativamente à análise morfológica do endotélio corneal, é possível observar que para todas as zonas em análise não existem diferenças estatisticamente significativas entre diabéticos e não diabéticos. Por último, não existe correlação dos fatores de risco associados à diabetes com as alterações ao nível do endotélio corneal.
Conclusão: A Diabetes Mellitus tipo 2 parece não interferir com a morfologia do endotélio corneal em qualquer das zonas corneais avaliadas. Além disso, neste mesmo estudo não existem fatores de risco associados à diabetes que se possam correlacionar com os parâmetros analisados.
Introduction: Diabetes Mellitus is a chronic disease whose prevalence has increased not only in Portugal but also globally it is important to understand its impact on the ocular surface. Several studies have analyzed the ocular changes caused by Diabetes Mellitus, and diabetic retinopathy is the 5th largest cause of blindness worldwide. However, since the changes in the anterior segment remain devalued compared to those of the posterior segment in the diabetic eye, one of the objectives of this study is the morphology quantification of corneal endothelium in individuals with type 2 Diabetes Mellitus for three corneal zones (central, paracentral and peripheral). Finally, another goal of this study is to understand if there is a correlation between the risk factors associated with diabetes and changes in the corneal endothelium. Methodology: Both groups in the study, diabetic and non-diabetic patients, signed an informed consent and were subject to prior assessment including slit lamp examination, measurement of intraocular pressure and retinography. The morphological analysis of corneal endothelium consisted of quantification of endothelial cell density, mean cell area, coefficient of variation and hexagonality of endothelial cells. These parameters were obtained for three zones of the cornea: central zone, paracentral zone and peripheral zone. Results: Regarding the morphological analysis of the corneal endothelium, it is possible to observe that for all the zones under analysis there are no statistically significant differences between diabetics and non-diabetics. Finally, there is no correlation between risk factors associated with diabetes and corneal endothelial changes. Conclusion: Type 2 Diabetes Mellitus does not appear to interfere with the morphology of the corneal endothelium in any of the corneal areas evaluated. In addition, in this same study, there are no risk factors associated with diabetes that can be correlated with the analyzed parameters.
Introduction: Diabetes Mellitus is a chronic disease whose prevalence has increased not only in Portugal but also globally it is important to understand its impact on the ocular surface. Several studies have analyzed the ocular changes caused by Diabetes Mellitus, and diabetic retinopathy is the 5th largest cause of blindness worldwide. However, since the changes in the anterior segment remain devalued compared to those of the posterior segment in the diabetic eye, one of the objectives of this study is the morphology quantification of corneal endothelium in individuals with type 2 Diabetes Mellitus for three corneal zones (central, paracentral and peripheral). Finally, another goal of this study is to understand if there is a correlation between the risk factors associated with diabetes and changes in the corneal endothelium. Methodology: Both groups in the study, diabetic and non-diabetic patients, signed an informed consent and were subject to prior assessment including slit lamp examination, measurement of intraocular pressure and retinography. The morphological analysis of corneal endothelium consisted of quantification of endothelial cell density, mean cell area, coefficient of variation and hexagonality of endothelial cells. These parameters were obtained for three zones of the cornea: central zone, paracentral zone and peripheral zone. Results: Regarding the morphological analysis of the corneal endothelium, it is possible to observe that for all the zones under analysis there are no statistically significant differences between diabetics and non-diabetics. Finally, there is no correlation between risk factors associated with diabetes and corneal endothelial changes. Conclusion: Type 2 Diabetes Mellitus does not appear to interfere with the morphology of the corneal endothelium in any of the corneal areas evaluated. In addition, in this same study, there are no risk factors associated with diabetes that can be correlated with the analyzed parameters.
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Keywords
Diabetes Mellitus Tipo 2 Fatores de Risco Microscopia Especular de Não Contacto Morfologia do Endotélio Corneal