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Abstract(s)
A doença de Alzheimer é uma disfunção neurodegenerativa multifactorial que é
caracterizada pelo declínio progressivo das funções cognitivas e a prevalência da
doença tem aumentado como consequência do aumento da esperança média de vida na
sociedade moderna. No presente estudo avaliaram-se os níveis séricos de homocisteína,
algumas vitaminas e hormonas, e de alguns parâmetros bioquímicos, bem como a
prevalência de algumas mutações em 17 doentes de Alzheimer e 25 controlos do Centro
Hospitalar Cova da Beira. A relação entre alguns dos parâmetros analisados foi também
investigada.
Este estudo evidenciou níveis mais elevados de homocisteína, colesterol e estradiol
(apenas nas mulheres) em doentes com patologia tipo Alzheimer relativamente aos
controlos.
Observou-se uma correlação positiva entre a homocisteína: e o cortisol (s=0,406;
0,010); a creatinina (s= 0,359; P=0,023), ácido úrico (s=0,461;P= 0,003) e testosterona
(s=0,324 ; P=0,041).
Na análise genética observou-se uma correlação positiva (P<0,05) na mutação do TCN2
num só alelo (genótipo CG), podendo estar associada negativamente à DA, podendo
constituir um factor protector de DA.
Alzheimer's disease is a multifactorial neurodegenerative dysfunction which is characterized by a progressive decline of cognitive functions and its prevalence has been increasing as a consequence of the increase in life expectancy in the modern society. In the present study it was evaluated the serum levels of homocysteine, some vitamins and hormones, and some biochemical parameters, as well as the prevalence of certain mutations in 17 Alzheimer's patients and 25 controls from the Centro Hospitalar Cova da Beira. The relationship between some of the parameters was also investigated. This study showed higher levels of homocysteine, cholesterol and estradiol (women only) in patients with Alzheimer disease relative to controls. We observed a positive correlation between homocysteine: and cortisol (s = 0.406, 0.010), creatinine (s = 0.359, P = 0.023), uric acid (s = 0.461, P = 0.003) and testosterone (s = 0.324; P = 0.041). In genetic analysis it was observed a positive correlation (P <0.05) in TCN2 mutation in one allele (genotype GC) and may be negatively associated with AD, may be a protective factor for AD.
Alzheimer's disease is a multifactorial neurodegenerative dysfunction which is characterized by a progressive decline of cognitive functions and its prevalence has been increasing as a consequence of the increase in life expectancy in the modern society. In the present study it was evaluated the serum levels of homocysteine, some vitamins and hormones, and some biochemical parameters, as well as the prevalence of certain mutations in 17 Alzheimer's patients and 25 controls from the Centro Hospitalar Cova da Beira. The relationship between some of the parameters was also investigated. This study showed higher levels of homocysteine, cholesterol and estradiol (women only) in patients with Alzheimer disease relative to controls. We observed a positive correlation between homocysteine: and cortisol (s = 0.406, 0.010), creatinine (s = 0.359, P = 0.023), uric acid (s = 0.461, P = 0.003) and testosterone (s = 0.324; P = 0.041). In genetic analysis it was observed a positive correlation (P <0.05) in TCN2 mutation in one allele (genotype GC) and may be negatively associated with AD, may be a protective factor for AD.
Description
Keywords
Doença de Alzheimer - Homocisteína Doença de Alzheimer - Vitamina B12 -- Vitamica C Doença de Alzheimer - Aspectos bioquímicos Doença de Alzheimer - Aspectos metabólicos Doença de Alzheimer - Aspectos endócrinos Doença de Alzheimer - Aspectos imunológicos Doença de Alzheimer - Aspectos genéticos