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Environmental risk factors associated with biliary atresia in Rio Grande do sul, Brazil
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Orientador(es)
Resumo(s)
Biliary atresia (BA) seems to be a multifactorial disorder in which environmental
factors interact with the patient’s genetic constitution. This study aimed to analyze
information concerning environmental risk factors associated with BA in southern Brazil.
A case-control study with mothers of patients with BA and mothers of patients with
cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition
to environmental risk factors during the periconceptional and gestational (second and
third trimesters) periods. Mothers of BA patients had smoked during pregnancy more
frequently in comparison with the mothers of CF patients, but no significant difference
was found in a multivariate analysis. There was no between group difference in terms
of seasonality, but the multivariate analysis showed a significant difference within
the BA group between date of conception in winter compared to other seasons. In
conclusion, smoking during pregnancy seemed to increase the risk of BA while date
of conception in winter decreased it.
Descrição
Palavras-chave
Biliary atresia Environmental risk factor Etiology Seasonality Smoking