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Environmental risk factors associated with biliary atresia in Rio Grande do sul, Brazil

2017Journal article Open access
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dc.contributor.authorLongo, Larisse
dc.contributor.authorFerrari, Jéssica Tonin
dc.contributor.authorHoss, Giovana Regina Weber
dc.contributor.authorFratta, Leila Xavier Sinigaglia
dc.contributor.authorVieira, Sandra Maria Gonçalves
dc.contributor.authorSilveira, Themis Reverbel da
dc.contributor.authorSilva, Fernando Antônio de Abreu e
dc.contributor.authorSanseverino, Maria Teresa
dc.contributor.authorSantos, Jorge Luiz dos
dc.date.accessioned2020-02-05T14:27:52Z
dc.date.available2020-02-05T14:27:52Z
dc.date.issued2017
dc.description.abstractBiliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.4322/2357-9730.71572pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9026
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBiliary atresiapt_PT
dc.subjectEnvironmental risk factorpt_PT
dc.subjectEtiologypt_PT
dc.subjectSeasonalitypt_PT
dc.subjectSmokingpt_PT
dc.titleEnvironmental risk factors associated with biliary atresia in Rio Grande do sul, Brazilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage90pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage87pt_PT
oaire.citation.titleClinical and Biomedical Researchpt_PT
oaire.citation.volume37pt_PT
person.familyNameSANSEVERINO
person.familyNamedos Santos
person.givenNameMARIA TERESA
person.givenNameJorge Luiz
person.identifier.orcid0000-0002-7404-2911
person.identifier.orcid0000-0002-3839-0222
person.identifier.ridG-3884-2017
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbb26976b-2b42-4905-90b7-09b79d6897ab
relation.isAuthorOfPublicatione2e81f33-a7b7-448c-a479-81afd7ca3378
relation.isAuthorOfPublication.latestForDiscoverye2e81f33-a7b7-448c-a479-81afd7ca3378

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