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Esta dissertação surge no culminar do meu percurso académico, e está introduzida na unidade curricular designada “Estágio” do Mestrado Integrado em Ciências Farmacêuticas. Este trabalho divide-se em dois capítulos, sendo o primeiro relativo ao trabalho de pesquisa bibliográfica, composto por uma revisão da literatura acerca da composição fitoquímica, usos na medicina tradicional, propriedades biológicas e toxicológicas da espécie Hamamelis virginiana. O segundo capítulo pretende descrever todas as competências técnicas desenvolvidas no âmbito da realidade farmacêutica, no estágio curricular em Farmácia Comunitária. O primeiro capítulo intitula-se de “Hamamelis virginiana: composição fitoquímica, usos na medicina tradicional, propriedades biológicas e toxicologia”. A espécie Hamamelis virginiana, da família Hamamelidáceas, é um arbusto ou árvore muito frequente nos bosques húmidos da zona norte e oriente dos EUA e do Canadá, sendo também, mais recentemente, cultivada na Europa. As partes mais usadas desta planta para fins medicinais são as folhas e as cascas. As folhas são constituídas por cerca de 3-10% de taninos (catequinas, hamamelitanino, elagiotaninos, galhotaninos, proantocianidinas), flavonóides e vestígios de óleo essencial. As cascas apresentam maior quantidade de taninos hidrolisáveis relativamente às folhas, vestígios de óleo essencial, flavonóides e saponósidos. Os taninos possuem propriedades adstringentes, cicatrizantes, venotrópicas e anti-radicalares. Estas propriedades permitem a sua aplicação tópica em casos de lesões e inflamações da pele e mucosas, em varizes, hemorróidas, queimaduras solares e eczema atópico. Além da ação dermatológica e em insuficiência venosa, também possui ação anti tumoral, anti-viral e antibacteriana. É também utilizado, sob a forma de extrato, em preparações cosméticas devido às suas propriedades adstringentes.
O segundo capítulo é referente ao estágio curricular que foi desenvolvido na Farmácia Bordalo, em Figueira de Castelo Rodrigo, num total de oitocentas horas. Neste capítulo descrevem-se todas as tarefas desempenhadas, assim como todos os conhecimentos adquiridos durante o estágio em Farmácia Comunitária.
This thesis represents the apex of my academic studies and it is a component of the curricular unit "Internship" from the Integrated Masters in Pharmaceutical Sciences. The document is divided into two main chapters. The first one, referred as bibliographical research, is composed by a literature review about the phytochemical composition, uses in traditional medicine, biological and toxicological properties of the species Hamamelis virginiana. The second chapter describes the experience lived within the scope of the curricular internship in Community Pharmacy. The first chapter is entitled "Hamamelis virginiana: phytochemical composition, uses in traditional medicine, biological properties and toxicology." The species Hamamelis virginiana, from the Hamamelidáceas family, is a common shrub or tree common in the humid forests of the northern and eastern US and Canada, and has been more recently cultivated in Europe. The parts of this plant most commonly used for medicinal purposes are leaves and bark. The leaves consist of about 3-10% of tannins (catechins, hamamelitanin, elagiotannins, galotanins, proanthocyanidins), flavonoids and traces of essential oil. The bark presents a higher amount of hydrolysable tannins relative to the leaves, traces of essential oil, flavonoids and saponosides. The tannins have astringent, healing, venotropic and anti-radicalar properties. These properties allow its topical application in cases of lesions and inflammations of the skin and mucous membranes, in varicose veins, hemorrhoids, sunburn, and atopic eczema. Besides the dermatological action, it also has anti-inflammatory, anti-tumoral, anti-viral and anti-bacterial action. It is also used, in the form of an extract, in cosmetic preparations because of its astringent properties. The second chapter refers to the internship accomplished at the Bordalo pharmacy in Figueira de Castelo Rodrigo, with a total of eight hundred hours. This chapter describes all the tasks performed, as well as all the knowledge acquired during the internship in Community Pharmacy.
This thesis represents the apex of my academic studies and it is a component of the curricular unit "Internship" from the Integrated Masters in Pharmaceutical Sciences. The document is divided into two main chapters. The first one, referred as bibliographical research, is composed by a literature review about the phytochemical composition, uses in traditional medicine, biological and toxicological properties of the species Hamamelis virginiana. The second chapter describes the experience lived within the scope of the curricular internship in Community Pharmacy. The first chapter is entitled "Hamamelis virginiana: phytochemical composition, uses in traditional medicine, biological properties and toxicology." The species Hamamelis virginiana, from the Hamamelidáceas family, is a common shrub or tree common in the humid forests of the northern and eastern US and Canada, and has been more recently cultivated in Europe. The parts of this plant most commonly used for medicinal purposes are leaves and bark. The leaves consist of about 3-10% of tannins (catechins, hamamelitanin, elagiotannins, galotanins, proanthocyanidins), flavonoids and traces of essential oil. The bark presents a higher amount of hydrolysable tannins relative to the leaves, traces of essential oil, flavonoids and saponosides. The tannins have astringent, healing, venotropic and anti-radicalar properties. These properties allow its topical application in cases of lesions and inflammations of the skin and mucous membranes, in varicose veins, hemorrhoids, sunburn, and atopic eczema. Besides the dermatological action, it also has anti-inflammatory, anti-tumoral, anti-viral and anti-bacterial action. It is also used, in the form of an extract, in cosmetic preparations because of its astringent properties. The second chapter refers to the internship accomplished at the Bordalo pharmacy in Figueira de Castelo Rodrigo, with a total of eight hundred hours. This chapter describes all the tasks performed, as well as all the knowledge acquired during the internship in Community Pharmacy.
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Keywords
Compostos Fenólicos Farmácia Comunitária Hamamelis Virginiana Medicina Tradicional Óleo Essencial