Browsing by Author "Ferreira, Joana Filipa Almeida"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- The link between event-related potentials and cognitive dysfunction in Multiple Sclerosis: A systematic reviewPublication . Ferreira, Joana Filipa Almeida; Patto, Maria da Assunção Morais e Cunha Vaz; Pinto, Nuno Filipe CardosoIntroduction: Multiple Sclerosis is one of the most frequent causes of Central Nervous System disease in young persons. It is associated with cognitive impairment in 70% of cases, resulting in a diminished quality of life. This systematic review aimed to evaluate if event-related potentials (ERPs) can be a relevant diagnosis tool of cognitive dysfunction in MS. Methods: Four databases were consulted (PubMed, Embase, Scielo and Web of Science) until March 10th, 2021. The research was made combining keywords, MESH or EMTREE terms. The inclusion criteria were 1) = 18 years old, 2) diagnosis according to specific MS criteria, 3) with or without cognitive complaints, 4) independently of the time of diagnosis and usual medication, and 5) articles written in Portuguese, Spanish, English and French. Papers should use ERPs, compared with normative values, Scales of Cognitive Evaluation and/or healthy control groups. The expected outcome was ERPs amplitude and/or latency variation (P300, N400 and mismatch negativity – MMN). Results: 425 articles were obtained initially, with 26 articles in the end. P300 was the most discussed ERP (25 articles), demonstrating a reduced amplitude or an increased latency in 84% of those. N400 was evaluated in one and MMN was addressed in two articles. ERPs were compared with Mini-Mental State Exam in two of them and with Montreal Cognitive Assessment in three. Other scales were also compared with ERPs in twenty articles. Conclusion: MS patients with cognitive impairment demonstrated overall ERP abnormalities, suggesting that ERPs may be an appropriate diagnostic method for cognitive impairment in MS.