Percorrer por autor "Lang, Jani Alexandra Saldanha Pombo"
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- Microscopic colitis: a clinical reviewPublication . Lang, Jani Alexandra Saldanha Pombo; Marcos, Pedro Miguel RibeiroIntroduction: Microscopic colitis (MC) is a growing inflammatory bowel disease (IBD) that significantly impacts patients' quality of life but remains underrecognized. Therefore, we proposed conducting a clinical review to summarize the available data regarding this condition. Methods: Review the published literature in PubMed. Systematic reviews, metaanalyses, randomized controlled trials, cohort studies, case-control studies, expert reviews, and guidelines were prioritized for analysis. Results: MC is characterized by chronic, watery, non-bloody diarrhea. Diagnosis involves ileocolonoscopy with biopsies from both the right and left colon. Collagenous colitis is identified by a collagen band thickness of 10 micrometers (µm) or more, while lymphocytic colitis has at least 20 intraepithelial lymphocytes (IEL) per 100 epithelial cells and a collagen band thickness of less than 10 µm. Both types show increased inflammatory infiltrate in the lamina propria. Incomplete MC includes cases with 10 to 20 IELs per 100 epithelial cells and a collagen band thickness between 5 and 10 µm. Treatment for MC typically involves avoiding triggers and taking budesonide, 9 mg daily for 6 to 8 weeks, with regular follow-up care needed for patients. Conclusions: Significant progress has been made in understanding MC. This review summarizes the current knowledge and provides a clear overview of the management of this condition.