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- ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practicePublication . Bousquet, Jean; Anto, Josep M.; Bachert, Claus; Haahtela, Tari; Zuberbier, Torsten; Czarlewski, Wienczyslawa; Bedbrook, Anna; Bosnic-Anticevich, Sinthia; Canonica, Giorgio Walter; Cardona, Victoria; Costa, Elísio; Farrell, John; Wroczynski, Piotr; Bjermer, Leif; Mair, Alpana; Lieberman, Philip; Odemyr, Mikaëla; Agache, Ioana; Larenas Linnemann, Désirée; Ventura, Maria Teresa; Makris, Michael; Samolinski, Boleslaw; Sofiev, Mikhail; Kvedarienė, Violeta; Carreiro-Martins, Pedro; Rolland, Christine; Usmani, Omar; Popov, Todor A; Williams, Dennis M; Sova, Milan; Manning, Patrick; Sheikh, Aziz; Pépin, Jean-Louis; Wagenmann, Martin; Mahboub, Bassam; Milenkovic, Branislava; Louis, Renaud; Laune, Daniel; Zidarn, Mihaela; Okamoto, Yoshitaka; Bonniaud, Philippe; Sisul, Juan; Ansotegui, Ignacio J; Stelmach, Rafael; Bennoor, Kazi Saifuddin; La Grutta, Stefania; O'Hehir, Robyn; De Manuel Keenoy, Esteban; Kleine-Tebbe, Joerg; Nyembue, Dieudonné; Passalacqua, Giovanni; Mitsias, Dimitirios I; Cecchi, Lorenzo; Novellino, Ettore; Buhl, Roland; Pinnock, Hilary; Klimek, Ludger; Ljungberg, Henrik; Akdis, Cezmi A; Gaga, Mina; Custovic, Adnan; Nordlund, Björn; Camargos, Paulo; Billo, Nils E.; Costa, David J; Briedis, Vitalis; Mogica-Martinez, Maria-Dolores; Panzner, Peter; Bourret, Rodolphe; Pham-Thi, Nhân; Schünemann, Holger J; Yorgancioglu, Arzu; Orlando, Valentina; Braido, Fulvio; Okubo, Kimihiro; To, Teresa; Ohta, Ken; Bindslev-Jensen, Carsten; D Bateman, Eric; Durham, Stephen R; Erhola, Marina; Yiallouros, Panayiotis; Cepeda Sarabia, Alfonso M; Lourenço, Olga; Cvetkosvki, Biljana; Napoli, Luigi; Roche, Nicolas; Salimäki, Johanna; Plavec, Davor; Morais-Almeida, Mario; Roberts, Graham; Scheire, Sophie; Camuzat, Thierry; Kull, Inger; Joos, Guy; Rivero-Yeverino, Daniela; Gomez, R Maximiliano; Somekh, David; Iinuma, Tomohisa; Portejoie, Fabienne; Neffen, Hugo; Cartier, Christine; Khaltaev, Nikolai; Rolland, Christine; Reitsma, Sietze; Dykewicz, Mark; Guldemond, Nick A; De Vries, Govert; Gevaert, Philippe; Rosario, Nelson; Fiocchi, Alessandro; De Feo, Giulia; Sastre, Joaquin; Emuzyte, Regina; Bosse, Isabelle; Zhang, Luo; Carriazo, Ana-Maria; Bewick, Michael; Rottem, Menachem; Fauquert, Jean-Luc; Calderon, Moises A; Roller-Wirnsberger, Regina E; Mullol, Joaquim; Rodriguez-Zagal, Erendira; Devillier, Philippe; Sousa, Jaime Correia de; Ebisawa, Motohiro; Kowalski, Marek L; Bedolla-Barajas, Martin; Huerta Villalobos, Yunuen R; Jung, Ki-Suck; Raciborski, Filip; Vezzani, Giorgio; Schmid-Grendelmeier, Peter; Psarros, Fotis; Carneiro, Antonio Vaz; Wong, Gary; Sooronbaev, Talant; Makela, Mika; Vasankari, Tuula; Zeng, Stéphane; Dokic, Dejan; Regateiro, Frederico S; Guzman, Maria Antonieta; Naclerio, Robert; Micheli, Yann; Vandenplas, Olivier; Malva, João; Illario, Maddalena; Menditto, Enrica; Spertini, François; Wickman, Magnus; Leonardini, Lisa; Heffler, Enrico; Basagaña, Xavier; Gotua, Maia; Wallace, Dana; Ivancevich, Juan-Carlos; Viart, Frédéric; Bonini, Matteo; Khaitov, Musa; Ierodiakonou, Despo; Münter, Lars; Courbis, Anne-Lise; Casale, Thomas; Mathieu-Dupas, Eve; Di Capua, Stefania; Miculinic, Neven; Valenta, Rudolf; Toppila-Salmi, Sanna Katriina; Zernotti, Mario E; Thibaudon, Michel; Tomazic, Peter Valentin; Annesi-Maesano, Isabella; Jutel, Marek; Quinones-Delgado, Pablo; Phillips, Jim; Todo-Bom, Ana; Onorato, Gabrielle L.; Benveniste, Samuel; Shan Zhong, Nan; Pereira, Marilyn Urrutia; Maspero, Jorge F; Prokopakis, Emmanuel P; Valiulis, Arunas; Suppli Ulrik, Charlotte; Muraro, Antonella; Palamarchuk, Julia; Mohammad, Yousser; Le Thi Tuyet, Lan; Neou, Angelo; Kuna, Piotr; Almeida, Rute; Namazova-Baranova, Leyla; Kritikos, Vicky; Chu, Derek K; Marshall, Gailen D; Kardas, Przemyslaw; Williams, Sian; Nekam, Kristof; Valovirta, Erkka; Dubakiene, Ruta; Tsiligianni, Ioanna; Montefort, Steve; Meltzer, Eli O; Murray, Ruth; Pugin, Benoit; Jassem, Ewa; Park, Hae-Sim; Picard, Robert; Brusselle, Guy; Arnavielhe, Sylvie; Patella, Vincenzo; Brozek, Jan; Carr, Warner; Bergmann, Karl-Christian; Melén, Erik; Brightling, Christopher E; H Chavannes, Niels; Moda, Giuliana; Pali-Schöll, Isabella; Valero, Antonio; Sofiev, Mikhail; Briggs, Andrew; Romano, Antonino; D'Amato, Gennaro; Shamji, Mohamed; Bialek, Slawomir; Caraballo, Luis; Rajabian-Söderlund, Rojin; Iaccarino, Guido; Ouedraogo, Solange; Buonaiuto, Roland; Silva, J da; Brussino, Luisa; Kouznetsov, Rostislav; Price, David; Paulino, Ema; Toumi, Mondher; Mercier, Jacques; Scadding, Glenis K; Monti, Ricardo; Solé, Dirceu; Boulet, Louis-Philippe; Gemicioglu, Bilun; Chkhartishvili, Ekaterine; Blain, Hubert; Fuentes Perez, José M; Humbert, Marc; Dantas, Carina; Yusuf, Osman; Fontaine, Jean-François; Viegi, Giovanni; Kaidashev, Igor; Cingi, Cemal; Boussery, Koen; Sanchez-Borges, Mario; Papadopoulos, Nikos G; Fokkens, Wytske J; Fink-Wagner, Antje; Wang, De Yun; Spranger, Otto; Cruz, Alvaro; Van Eerd, Michiel; Dauvilliers, Yves; Hajjam, Jawad; Valentin Rostan, Marylin; Puggioni, Francesca; Melo-Gomes, Elisabete; Ryan, Dermot; González Diaz, Sandra; Van Der Kleij, Rianne; Garcia-Aymerich, Judith; Mösges, Ralph; Gamkrelidze, Amiran; Stellato, Cristiana; Sarquis Serpa, Faradiba; Niedoszytko, Marek; Pfaar, Oliver; Pawankar, Ruby; Zar, Heather J; Loureiro, Claudia C; Fonseca, Joao A; El-Gamal, Yehia; Lopes-Pereira, Catarina; Masjedi, Mohamed R; Kalayci, Omer; Dray, Gerard; Carlsen, Karin C. Lodrup; Maurer, Marcus; Waserman, Susan; Bouchard, Jacques; Becker, Sven; Lipworth, Brian; Walker, Samantha; Mihaltan, Florin; Bédard, Annabelle; Keil, ThomasDigital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
- Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platformsPublication . Bousquet, Jean; Schröder-Bernhardi, Detlef; Bachert, Claus; Canonica, G Walter; Cardona, Victoria; Costa, Elísio; Czarlewski, Wienczyslawa; Devillier, Philippe; Fonseca, Joao A; Klimek, Ludger; Kuna, Piotr; Lourenço, Olga; Mullol, Joaquim; Pfaar, Oliver; Pham-Thi, Nhân; Samolinski, Boleslaw; Saueressig, Julia; Scadding, Glenis K; Stroh, Ann-Kathrin; Scheire, Sophie; Van Ganse, Eric; Zuberbier, TorstenBackground: The practice of allergology varies widely between countries, and the costs and sales for the treatment of rhinitis differ depending on practices and health systems. To understand these differences and their implications, the rhinitis market was studied in some of the EU countries. Methods: We conducted a pharmaco-epidemiological database analysis to assess the medications that were being prescribed for allergic rhinitis in the years 2016, 2017 and 2018. We used the IQVIA platforms for prescribed medicines (MIDAS®- Meaningful Integration of Data, Analytics and Services) and for OTC medicines (OTC International Market Tracking-OTCims). We selected the five most important markets in the EU (France, Germany, Italy, Poland and Spain). Results: Intranasal decongestants were excluded from the analyses because they are rarely prescribed for allergic rhinitis. For both Standard Units (SU) and costs, France is leading the other countries. In terms of SU, the four other countries are similar. For costs, Poland is lower than the three others. However, medication use differs largely. For 2018, in SU, intranasal corticosteroid is the first treatment in Poland (70.0%), France (51.3%), Spain (51.1%) and Germany (50.3%), whereas the Italian market is dominated by systemic antihistamines (41.4%) followed by intranasal corticosteroids (30.1%). Results of other years were similar. Discussion: There are major differences between countries in terms of rhinoconjunctivitis medication usage.
- Management of allergic rhinitis symptoms in the pharmacy Pocket guide 2022Publication . Lourenço, Olga; Cvetkovski, Biljana; Kritikos, Vicky; House, Rachel; Scheire, Sophie; Costa, Elísio; Fonseca, Joao A; Menditto, Enrica; Bedbrook, Anna; Bialek, Slawomir; Briedis, Vitalis; Boussery, Koen; Canonica, G. Walter; Haahtela, Tari; Kuna, Piotr; Mullol, Joaquim; Orlando, Valentina; Samolinski, Boleslaw; Wallace, Dana; Duggan, Catherine; Paulino, Ema; Pinto, Gonçalo S.; Söderlund, Lars‐Åke; Bousquet, Jean; Bosnic‐Anticevich, SinthiaBackground: Allergic rhinitis (AR) management requires a coordinated effort from healthcare providers and patients. Pharmacists are key members of these integrated care pathways resolving medication-related problems, optimizing regimens, improving adherence and recommending therapies while establishing liaisons between patients and physicians. Methods: Allergic Rhinitis and its Impact on Asthma (ARIA) first published a reference document on the pharmacist's role in allergic rhinitis management in 2004. Several guidelines were developed over the past 20 years improving the care of allergic rhinitis patients through an evidence-based, integrated care approach. Results: This ARIA/EAACI/FIP Position Paper is based on the latest ARIA in the Pharmacy guidelines and provides: (a) a structured approach to pharmacists identifying people with AR and/or allergic conjunctivitis as well as those at risk of poor disease control; (b) an evidence-based clinical decision support tool for optimising the management of allergic rhinitis in the community pharmacy; and (c) a framework of referral to the physician. Conclusion: This document is not intended to be a mandatory standard of care but is provided as a basis for pharmacists and their staff to develop relevant local standards of care for their patients, within their local practice environment. Pharmacy care varies between countries, and the guide should be adapted to the local situation.
- Managing Allergic Rhinitis in the Pharmacy: An ARIA Guide for Implementation in PracticePublication . Lourenço, Olga; Bosnic-Anticevich, Sinthia; Costa, Elísio; Fonseca, Joao A; Menditto, Enrica; Cvetkovski, Biljana; Kritikos, Vicky; Tan, Rachel; Bedbrook, Anna; Scheire, Sophie; Bachert, Claus; Białek, Sławomir; Briedis, Vitalis; Boussery, Koen; Canonica, G Walter; Haahtela, Tari; Kuna, Piotr; Novellino, Ettore; Samolinski, Boleslaw; Schünemann, Holger J; Wallace, Dana; Bousquet, JeanThe paradigm of how we manage allergic rhinitis is shifting with a growing understanding that it is a complex process, requiring a coordinated effort from healthcare providers and patients. Pharmacists are key members of these integrated care pathways resolving medication-related problems, optimizing regimens, improving adherence and recommending therapies while establishing liaisons between patients and physicians. Community pharmacists are the most accessible healthcare professionals to the public and allergic rhinitis is one of the most common diseases managed by pharmacists. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines developed over the past 20 years have improved the care of allergic rhinitis patients through an evidence-based, integrated care approach. In this paper, we propose an integrated approach to allergic rhinitis management in community pharmacy following the 2019 ARIA in the pharmacy guidelines.
- Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesisPublication . Bousquet, Jean; Melén, Erik; Haahtela, Tari; Koppelman, Gerard; Togias, Alkis; Valenta, Rudolf; Akdis, Cezmi; Czarlewski, Wienczyslawa; Rothenberg, Marc; Valiulis, Arunas; Wickman, Magnus; Aberer, Werner; Heinrich, Joachim; Sisul, Juan; Nunes, Elizabete; Plavec, Davor; Agache, Ioana; Al-Ahmad, Mona; Serpa, Faradiba; Alobid, Isam; Kalayci, Omer; Vichyanond, Pakit; Giacco, S. Del; Fiocchi, Alessandro; Ansotegui Zubeldia, Ignacio Javier; Custovic, Adnan; Martins, Pedro Carreiro; Rouadi, Philip; Arshad, Syed Hasan; Asayag, Estrella; Bárbara, Cristina; Abdullah, Baharudin; Moniuszko, Marcin; Tomazic, Peter Valentin; Popov, T. A.; Sayah, Zineb; Lkhagvaa, Battur; Nyembue Tshipukane , Dieudonne; Thomas, Mike; Bennoor, Kazi Saifuddin; Fyhrquist, Nanna Theresia; Irani, Carla; Berghea, Elena Camelia; Ėmužytė, Regina; De Blay, Frédéric; Toppila-Salmi, Sanna Katriina; Bergmann, Karl-Christian; Bernstein, D.; Bewick, M.; Casale, Thomas; Scheire, Sophie; Bumbacea, Roxana Silvia; Cepeda Sarabia, Alfonso; Puggioni, Francesca; Bush, Andrew; Chandrasekharan, Ramanathan; Ohta, Ken; Okubo, Kimihiro; Charpin, Denis; Gomez, R Maximiliano; Chen, Y. Z.; O'Hehir, Robyn; Cherrez Ojeda, Ivan; Bedbrook, Anna; To, Teresa; Chu, Derek K; Devillier, Philippe; Schmid-Grendelmeier, Peter; Didier, Alain; Repka-Ramirez, María Susana; Teixeira, Maria Do Céu; Ispayeva, Zhanat; Dokic, Dejan; Quirce, Santiago; Douagui , Habib; Ivancevich, Juan Carlos; Viegi, Giovanni; Gotua, Maia; Todo-Bom, Ana; Blain, Hubert; Guzman, Maria Antonieta; Kalyoncu, Ali Fuat; Hagemann, Jan; Buhl, Roland; Hamamah, Samir; Caraballo, Luis; Jares, Edgardo; Wallace, Dana; Chivato, Tomás; Jartti, Tuomas; Jassem, Ewa; Christoff, George; Julge, Kalev; Ogulur, Ismail; Kardas, Przemyslaw; Doulaptsi, Maria; Kirenga, Bruce; Helga, Kraxner; Durham, Stephen; Kull, Inger; Kulus, Marek; Daniel, Aguilar; Shamji, Mohamed; Kuna, Piotr; Nadif, Rachel; La Grutta, Stefania; Brightling, Chris; Samoliński, Bolesław; Lau, Susanne; Wang, De Yun; Cordeiro, Carlos Manuel Da Silva Robalo; Solé, Dirceu; Le Thi Tuyet, Lan; Recto, Marysia; Ouedraogo, Solange; Halken, Susanne; Levin, Michael; Lipworth, Brian; Lourenço, Olga; Mahboub, Bassam; Vandenplas, O.; Niedoszytko, Marek; Sastre, Joaquin; Martinez‐Infante, E.; Kupczyk, Maciej; Torres, María Jose; Matricardi, Paolo Maria; Cecchi, Lorenzo; Celedón, Juan C; Miculinic, Neven; Roche, Nicolas; Just, Jocelyne; Migueres, Nicolas; Brussino, Luisa; Florin, Mihaltan; Olze, Heidi; Savouré, Marine; Nekam, Kristof; Pali, Isabella; Okamoto, Yoshitaka; Palomares, O.; Lemonnier, Nathanaël; Carlsen, Karin C. Lodrup; Palosuo, Kati; Soto-Martinez, Manuel; Panaitescu, Carmen; Kvedarienė, Violeta; Panzner, P.; Braido, Fulvio; Tsiligianni, Ioanna; Rodriguez-Gonzalez, Monica; Scichilone, Nicola; Canonica, Giogio Walter; Passalacqua, Giovanni; Romantowski, Jan; Urrutia-Pereira, Marilyn; Filho, Nelson Augusto Rosario; Ollert, Markus W.; Rottem, Menachem; Chkhartishvili, Ekaterine; Sova, Milan; Valovirta, Erkka; Mohammad, Yousser; Sperl, Annette; Williams, Siân; Spranger, Otto; Neffen, Hugo; Stelmach, Rafael; Burte, Emilie; Valentin Rostan, Marylin; Park, Hae-Sim; Van Ganse, Eric; Van Hage, Marianne; Pitsios, Constantinos; Vasankari, Tuula; Linnemann, Désirée Larenas; Loureiro, Cláudia Chaves; Sagara, Hironori; Worm, Margitta; Yiallouros, Panayiotis; Yusuf, Osman; Zaitoun, Fares; Bonini, Matteo; Hrubiško, Martin; Cingi, C.; Dykewicz, Mark; Zernotti, Mario; Calderon, Moises; Halpin, David M.G.; Zidarn, Mihaela; Patella, Vincenzo; Sheikh, Aziz; Zuberbier, Jaron; Papadopoulos, Nikolaos; Louis, Renaud; Suppli Ulrik, Charlotte; Fonseca, João P.; Zuberbier, Torsten; Anto, Josep M.; Costa, Elisio; Eiwegger, Thomas; Bosnic-Anticevich, Sinthia; Cruz, Alvaro; Sousa, Jaime Correia de; Louis-Philippe, Boulet; Erhola, Marina; Cardona, Victoria; Carr, Warner; Gemicioglu, Bilun; Pawankar, Ruby; Fokkens, Wytske; Calvo, Mário; Garcia-Aymerich, J.; Mäkelä, Mika J.; Hofmann, Maja Ann; Klimek, Ludger; Makris, Michael; Mohamed Sayed, Zeinab; Maurer, Marcus; D'Amato, G.; Momas, Isabelle; Siroux, Valérie; Almeida, Mário Morais; Corrigan, Chris; Mullol, Joaquim; Montefort, Stephen; Jutel, Marek; Pham Thi, Nhan; Hossny, Elham; Akdis, Mubeccel; Pfaar, Oliver; Ventura, Maria Teresa; Regateiro, Frederico S.; Bindslev-Jensen, Carsten; Ring, Johannes; Bustamante, Mariona; Pinto, Bernardo Sousa; Kaidashev, Igor; Guerra, Stefano; Standl, Marie; Sunyer, J.; Keil, Thomas; Barata, Luís Taborda; Camargos, Paulo; Weiss, Scott; Naclerio, Robert; Yorgancıoglu, Arzu; Zhang, Luo; Nadeau, Kari; Abdul Latiff, AmirAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.